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Pentoxifylline Protects Against Hippocampal Damage and Memory Impairment Induced by Trimethyltin.
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- معلومة اضافية
- نبذة مختصرة :
Background: Trimethyltin (TMT) is a toxic agent that causes oxidative stress, a laboratory model for inducing hippocampal injuries. Pentoxifylline (PTX) inhibits phosphodiesterase, inflammation and oxidative stress. This study evaluated the neuroprotective effects of PTX on injuries induced by TMT in the hippocampus. Methods: Sixty male Wistar rats were divided into five groups of 12 each. Group 1 received normal saline while Group 2 received a single dose of TMT (8 mg/kg). The other four groups received TMT at 8 mg/kg plus 60, 100 or 120 mg/kg PTX twice daily for six consecutive days. The rats' working and reference memory were investigated, using radial arm maze tasks. At the end of the experiments, the rats' brains were removed and processed for histological study of the hippocampus. Results: The TMT treatment prolonged the four baited arms tasks (P<0.001), while the PTX treatment at 60, 100 or 120 mg/kg significantly reduced the effects of TMT on the spatial memory (P<0.01). The working and reference memory errors significantly increased in the TMT group compared to the controls (P<0.001) while the PTX treatment significantly reduced the TMT effect (P<0.001). Also, TMT increased the number of pyknotic cells in the hippocampus (P<0.001), while PTX significantly decreased the mean number of pyknotic cells (P<0.05). Conclusion: The findings suggest that PTX can protect against the memory deficit and deleterious effects on rat hippocampus induced by TMT neurotoxicity. Thus, PTX is likely to be a potential agent to prevent against the neurotoxicity induced by TMT. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
Copyright of Iranian Journal of Toxicology is the property of Arak University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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