Effect of uvulopalatopharyngoplasty (UPPP) on atherosclerosis and cardiac functioning in obstructive sleep apnea patients.

Background: Obstructive sleep apnea (OSA) is associated with several cardiovascular comorbidities including hypertension, arteriosclerosis, and heart failure. Uvulopalatopharyngoplasty (UPPP) is a frequently performed surgical treatment for OSA. Aims/Objectives: To analyze if UPPP can improve cardiac parameters associated with atherosclerosis and reduce the cardiac burden in OSA patients. Material and methods: A prospective cohort study was performed at a single tertiary care center where OSA patients undergoing UPPP were evaluated. Preoperative and 6-month postoperative cardiac parameters namely carotid artery intima-media thickness (CIMT), arterial stiffness parameters, echocardiography, and polysomnography (PSG) results were compared. Results: Fifty three patients were included in the study. The success and response rate of UPPP was 60.4%. Following the surgery, significant reduction in arterial stiffness index (β) (12.4 ± 4.1 vs. 11.2 ± 4.0, p =.01), and elasticity modulus (Ep) (172.8 ± 68.3 vs. 156.6 ± 55.3, p =.05) was noticed. Additionally, echocardiographic parameters namely velocity across aortic valve (121.9 ± 22.9 vs. 109.4 ± 17.7, p =.01) and velocity across pulmonary valve (107.4 ± 16.4 vs. 94.2 ± 16.9, p <.01) significantly decreased following UPPP. Conclusions and significance: UPPP significantly improves parameters related to carotid atherosclerosis and has the potential to reduce cardiac burden in OSA patients. [ABSTRACT FROM AUTHOR]

背景：阻塞性睡眠呼吸暂停（OSA）与多种心血管合并症有关, 包括高血压、动脉硬化和心力衰竭。悬雍垂腭咽成形术（UPPP）是经常进行的OSA手术治疗。 目的：分析UPPP是否可以改善与动脉粥样硬化相关的心脏参数, 并减少OSA患者的心脏负担。 材料和方法：一项前瞻性队列研究在一个三级医疗中心进行, 对接受UPPP的OSA患者进行了评估。对术前和术后6个月的心脏参数, 即颈动脉内膜中层厚度（CIMT）、动脉硬度参数、超声心动图和多导睡眠图（PSG）结果, 进行了比较。 结果：53名患者被纳入研究。 UPPP的成功率和响应率为60.4％。手术后, 动脉僵硬度指数（β）显著降低（12.4±4.1 对 11.2±4.0, p =.01）, 并注意到弹性模量（Ep）（172.8±68.3 对 156.6±55.3, p =.05）。此外, 超声心动图参数即主动脉瓣的速度（121.9±22.9对109.4±17.7, p =.01）和肺动脉瓣的速度（107.4±16.4对94.2±16.9, p <.01）在UPPP术后显著下降。 结论和意义：UPPP显著改善与颈动脉粥样硬化相关的参数, 并有可能减少OSA患者的心脏负担。 [ABSTRACT FROM AUTHOR]

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