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Treatment Refusal and Abandonment Remain Major Concerns Despite Good Outcomes with Multi‑Modality Management in Pediatric Medulloblastoma: Experience from a Cancer Center in Eastern India.
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- معلومة اضافية
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- نبذة مختصرة :
Context: Survival in medulloblastoma, the most common pediatric brain tumor, has lagged behind in developing countries in comparison to the West. Aim: The aim of this study was to analyze the clinical profile and outcome in a cancer center in Eastern India. Methods: Twenty‑nine children were retrospectively analyzed over 6 years. Results: Vomiting (79%), headache (69%), and unsteadiness (55%) were the presenting complaints. The majority (67%) had classical histology. High‑risk (HR) disease (61.6%) exceeded average‑risk (AR) (38.4%) disease in numbers. Treatment‑refusal (27.6%) and abandonment (6.9%) were major concerns. Four‑year EFS was 81% and 52%, excluding and including refusal/abandonment, respectively. There was no relapse/progression among AR patients. Four‑year EFS in HR was 63%. Posterior fossa syndrome (37.5%), febrile neutropenia (29%), and ototoxicity (16.7%) were the main treatment‑related morbidities. Implications: Following this audit, patient tracking to reduce abandonment, coordination to limit delay in postsurgical referral, developing strategies for molecular subgrouping, and reducing cumulative cisplatin exposure were measures adopted to improve outcome in the unit. [ABSTRACT FROM AUTHOR]
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Copyright of Indian Journal of Medical & Paediatric Oncology is the property of Thieme Medical & Scientific Publishers Private Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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