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DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
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- المؤلفون: Bian, Ke1 (AUTHOR); Lenz, Stefan A P2 (AUTHOR); Tang, Qi1 (AUTHOR); Chen, Fangyi1 (AUTHOR); Qi, Rui1 (AUTHOR); Jost, Marco3 (AUTHOR); Drennan, Catherine L4 (AUTHOR); Essigmann, John M5 (AUTHOR); Wetmore, Stacey D2 (AUTHOR) ; Li, Deyu1 (AUTHOR)
- المصدر:
Nucleic Acids Research. 6/20/2019, Vol. 47 Issue 11, p5522-5529. 8p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Highlights from the article: DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro. DNA repair enzymes ALKBH2, ALKBH3, and AlkB Proteins--the DNA repair enzymes in the AlkB fam- Crystal structures of the AlkB enzymes indicate the lesions That the AlkB enzymes can not only repair DNA lesions.
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