DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.

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المؤلفون: Bian, Ke¹ (AUTHOR); Lenz, Stefan A P² (AUTHOR); Tang, Qi¹ (AUTHOR); Chen, Fangyi¹ (AUTHOR); Qi, Rui¹ (AUTHOR); Jost, Marco³ (AUTHOR); Drennan, Catherine L⁴ (AUTHOR); Essigmann, John M⁵ (AUTHOR); Wetmore, Stacey D² (AUTHOR) ; Li, Deyu¹ (AUTHOR)
المصدر:
Nucleic Acids Research. 6/20/2019, Vol. 47 Issue 11, p5522-5529. 8p.
الموضوع:
*DNA ligases; *TIME-of-flight mass spectrometry; *ELECTROSPRAY ionization mass spectrometry; *TRYPSIN; *DNA methyltransferases

معلومة اضافية
- نبذة مختصرة :
  Highlights from the article: DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro. DNA repair enzymes ALKBH2, ALKBH3, and AlkB Proteins--the DNA repair enzymes in the AlkB fam- Crystal structures of the AlkB enzymes indicate the lesions That the AlkB enzymes can not only repair DNA lesions.