The Effect of circuit resistance training with Medicago sativa extracts on levels of osteoprotegerin and nuclear factor of Kappa-B in thin girls.

Introduction: Osteoporosis is the most prevalent metabolic bone disease with multiple factors involved in its , including low body mass index and lack of physical activity. Changes in lifestyle represents a successful strategy to prevent osteoporosis. Therefore, this study aimed to determine the interactive effects of resistance training and Medicago sativa extracts on serum level of osteoprotegerin and nuclear factor kappa B in thin girls. Materials and Methods: In this quasi-experimental study, 28 female students (16 to 19 years) were divided randomly into four groups of supplement, training, training-supplement and control. Resistance training program comprised 10 exercise movements at 60%-80% of one repeated maximal in 8-12 repetition (in 3 circuits), 60 min per day and 3 sessions per week for 4 weeks. Medicago sativa supplement was taken as 1 ml/kg body weight for 3 times a day. Data were analyzed with paired t and ANOVA tests. Results: Four weeks of resistance training, supplementation and the combined ntervention were associated with a significant increase in osteoprotegerin and decrease in nuclear factor kappa B levels (P< 0/05) in thin girls. Furthermore, combined intervention was associated with greater changes in these inducators in comparison with training and supplement groups (p< 0.05). Conclusion: Regular resistance training with onsumption of Medicago sativa extracts as a non-medical therapy can increase bone formation markers and also reduce the activity of the absorbency pathway in thin adolescent girls. Of course the combination of exercise and supplement are more effective than the separate affects of eachs them. [ABSTRACT FROM AUTHOR]