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Long-term outcome of pediatric obsessive–compulsive disorder: a meta-analysis and qualitative review of the literature.
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- المؤلفون: Stewart, S. E.1,2,3,4 (AUTHOR); Geller, D. A.1,3,5 (AUTHOR); Jenike, M.2,3,6 (AUTHOR); Pauls, D.3,4 (AUTHOR); Shaw, D.7 (AUTHOR); Mullin, B.7 (AUTHOR); Faraone, S. V.3,5 (AUTHOR)
- المصدر:
Acta Psychiatrica Scandinavica. Jul2004, Vol. 110 Issue 1, p4-13. 10p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Stewart SE, Geller DA, Jenike M, Pauls D, Shaw D, Mullin B, Faraone SV. Long-term outcome of pediatric obsessive–compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand 2004: 110: 4–13. © Blackwell Munksgaard 2004. To review the extant literature on the long-term outcome of child/adolescent-onset obsessive–compulsive disorder (OCD). Medline and Psychlit databases were systematically searched for articles regarding long-term outcomes of child/adolescent-onset OCD. Meta-analysis regression was applied to evaluate predictors and persistence of OCD. Sixteen study samples ( n = 6–132; total = 521 participants) in 22 studies had follow-up periods ranging between 1 and 15.6 years. Pooled mean persistence rates were 41% for full OCD and 60% for full or subthreshold OCD. Earlier age of OCD onset ( z = −3.26, P = 0.001), increased OCD duration ( z = 2.22, P = 0.027) and in-patient vs. out-patient status ( z = 2.94, P = 0.003) predicted greater persistence. Comorbid psychiatric illness and poor initial treatment response were poor prognostic factors. Although psychosocial function was frequently compromised, most studies lacked comprehensive outcome measures. Long-term persistence of pediatric OCD may be lower than believed. Future studies should include broader measures of outcome including symptomatic persistence and functional impairment in multiple domains. [ABSTRACT FROM AUTHOR]
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