Cell-mediated lympholysis in vitro. Independence of mixed lymphocyte reactions and T-cell mitogen responses from the in vitro generation of cytotoxic effectors in primary immunodeficiency diseases.

Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE

Publication: 2022- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Scientific Publications

Immunity, Cellular*; Immunologic Deficiency Syndromes/*immunology ; Lymphocytes/*immunology; Cytotoxicity Tests, Immunologic ; Humans ; Lectins/pharmacology ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Receptors, Antigen, B-Cell/analysis ; T-Lymphocytes/analysis ; T-Lymphocytes/immunology

Cell-mediated lympholysis (CML) in eighteen patients suffering from primary immune deficiencies was studied. Fourteen of these patients had the variable type. Mixed lymphocyte response (MLR) and CML were clearly found to be independent: as well as two groups of patients in whom the two functions were either both normal or both deficient, two other groups were found in whom they were definitely separate. In one group MLR and T-cell mitogen responses were normal but no CML occurred against allogenic lymphocytes, and in the other cytotoxic effectors were generated normally but MLR and T-cell mitogen responses were very much lower than normal. These results show that the functions are independent, and are compatible with the theory that more than one subpopulation of T cells is involved. Neither the MLR or T-cell mitogen responses of these patients can predict their ability to generate cytotoxic effectors.

Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031-5. (PMID: 4399834)
Eur J Immunol. 1974 May;4(5):378-87. (PMID: 4277395)
Transplant Proc. 1972 Jun;4(2):209-18. (PMID: 4556065)
Immunology. 1968 Feb;14(2):181-96. (PMID: 4966657)
J Exp Med. 1972 Apr 1;135(4):890-906. (PMID: 5018054)
J Immunol. 1972 Sep;109(3):630-7. (PMID: 5055183)
G Batteriol Virol Immunol. 1971 Sep-Dec;64(9):243-54. (PMID: 5155939)
Science. 1970 Apr 3;168(3927):133-5. (PMID: 5417055)
Science. 1970 Dec 25;170(3965):1406-9. (PMID: 5529745)
J Exp Med. 1970 Dec 1;132(6):1107-21. (PMID: 5534448)
J Pediatr. 1968 Feb;72(2):177-85. (PMID: 5635802)
Pediatrics. 1971 May;47(5):927-46. (PMID: 4102352)
J Immunol. 1973 Feb;110(2):362-75. (PMID: 4119248)
Transplant Proc. 1973 Mar;5(1):415-20. (PMID: 4121172)
Transplant Proc. 1973 Dec;5(4):1675-8. (PMID: 4130075)
Transplant Proc. 1973 Dec;5(4):1683-9. (PMID: 4130077)
Transplantation. 1974 Sep;18(3):256-66. (PMID: 4138893)
Adv Immunol. 1974;18:67-132. (PMID: 4151339)
Transplant Rev. 1973;17(0):3-36. (PMID: 4151904)
J Immunol. 1973 Mar;110(3):652-60. (PMID: 4265964)
Nat New Biol. 1973 Feb 28;241(113):279-81. (PMID: 4266428)
Science. 1973 Apr 27;180(4084):403-6. (PMID: 4267047)
J Exp Med. 1973 May 1;137(5):1303-9. (PMID: 4267208)
Br Med J. 1973 Oct 6;4(5883):48-9. (PMID: 4273273)
J Exp Med. 1972 Apr 1;135(4):764-79. (PMID: 4401604)

0 (Lectins)
0 (Receptors, Antigen, B-Cell)

Date Created: 19750401 Date Completed: 19760330 Latest Revision: 20181113

20221213

PMC1538186

128428