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Clinical value of ALU concentration and integrity index for the early diagnosis of ovarian cancer: A retrospective cohort trial.
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- المؤلفون: Zhang, Rong1; PU, Wangyang2; Zhang, Shuyun1; Chen, Li1; Zhu, Weipei1; Xiao, Li3; Xing, Chungen4 ; Li, Kai3
- المصدر:
PLoS ONE. 2/5/2018, Vol. 13 Issue 2, p1-9. 9p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
CA125 amounts have a large overlap in ovarian cancer and benign diseases. We conducted a retrospective cohort trial to assess the clinical value of circulating cell-free DNA concentration and integrity index for the diagnosis of ovarian cancer. A total of 150 patients were recruited. Plasma samples of 24 ovarian cancer patients, 12 benign ovarian cysts, and 12 healthy controls were assessed. By amplifying short ALU-115 repeat and long ALU-219 fragments, circulating cell-free DNA concentrations and integrity index were measured. Plasma ALU-219 fragment levels and integrity index were significantly higher in the ovarian cancer group compared with the benign disease and healthy control groups (p = 0.023 and p = 0.004, respectively). These findings indicated that plasma ALU-219 levels and integrity may have a clinical value in the early diagnosis of ovarian cancer. [ABSTRACT FROM AUTHOR]
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