Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effects of ageing and long-term hormone replacement on cholinergic neurones in the medial septum and nucleus basalis magnocellularis of ovariectomized rats.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Gibbs RB;Gibbs RB
  • المصدر:
    Journal of neuroendocrinology [J Neuroendocrinol] 2003 May; Vol. 15 (5), pp. 477-85.
  • نوع النشر :
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley & Sons Country of Publication: United States NLM ID: 8913461 Publication Model: Print Cited Medium: Print ISSN: 0953-8194 (Print) Linking ISSN: 09538194 NLM ISO Abbreviation: J Neuroendocrinol Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2010->: Malden, MA : Wiley & Sons
      Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989-
    • الموضوع:
      Aging* ; Estrogen Replacement Therapy*; Acetylcholine/*physiology ; Basal Nucleus of Meynert/*cytology ; Neurons/*cytology ; Septum Pellucidum/*cytology; Animals ; Cell Count ; Cell Size ; Cell Survival ; Choline O-Acetyltransferase/genetics ; Estradiol/administration & dosage ; Estradiol/blood ; Female ; Neurons/physiology ; Ovariectomy ; RNA, Messenger/analysis ; Rats ; Rats, Sprague-Dawley ; Receptor, trkA/genetics
    • نبذة مختصرة :
      Ovariectomized aged rats, some of which received long-term hormone replacement with oestrogen or oestrogen plus progesterone, were evaluated for the number and size of basal forebrain cholinergic neurones, as well as relative levels of choline acetyltransferase (ChAT) and trkA mRNA, in order to determine whether effects on basal forebrain cholinergic cell survival and function correspond with differences in cognitive performance previously described. The results show that ageing combined with long-term loss of ovarian function produced substantial reductions in the levels of ChAT and trkA mRNA in the medial septum and nucleus basalis magnocellularis, relative to much younger ovariectomized controls. In contrast, no significant effects on the number or size of the cholinergic cells were detected, indicating that loss of ovarian function does not cause a loss of cholinergic neurones with age. Long-term hormone replacement had no apparent effect on the number of ChAT-positive neurones detected, and did not prevent the reductions in ChAT and trkA mRNA associated with ovariectomy and ageing. Collectively, the data suggest that ageing combined with long-term loss of ovarian function has a severe negative impact on basal forebrain cholinergic function, but not on cholinergic cell survival per se.
    • Grant Information:
      NS28896 United States NS NINDS NIH HHS
    • الرقم المعرف:
      0 (RNA, Messenger)
      4TI98Z838E (Estradiol)
      EC 2.3.1.6 (Choline O-Acetyltransferase)
      EC 2.7.10.1 (Receptor, trkA)
      N9YNS0M02X (Acetylcholine)
    • الموضوع:
      Date Created: 20030416 Date Completed: 20030807 Latest Revision: 20190922
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1046/j.1365-2826.2003.01012.x
    • الرقم المعرف:
      12694373