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The Sister Study Cohort: Baseline Methods and Participant Characteristics.
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- المؤلفون: Sandler, Dale P.1 ; Hodgson, M. Elizabeth2; Deming-Halverson, Sandra L.2; Juras, Paula S.1; D'Aloisio, Aimee A.2; Suarez, Lourdes M.2; Kleeberger, Cynthia A.2; Shore, David L.3; DeRoo, Lisa A.4; Taylor, Jack A.1; Weinberg, Clarice R.5
- المصدر:
Environmental Health Perspectives. Dec2017, Vol. 125 Issue 12, p1-11. 11p. 1 Diagram, 5 Charts.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
BACKGROUND: The Sister Study was designed to address gaps in the study of environment and breast cancer by taking advantage of more frequent breast cancer diagnoses among women with a sister history of breast cancer and the presumed enrichment of shared environmental and genetic exposures. OBJECTIVE: The Sister Study sought a large cohort of women never diagnosed with breast cancer but who had a sister (full or half) diagnosed with breast cancer. METHODS: A multifaceted national effort employed novel strategies to recruit a diverse cohort, and collected biological and environmental samples and extensive data on potential breast cancer risk factors. RESULTS: The Sister Study enrolled 50,884 U.S. and Puerto Rican women 35-74 y of age (median 56 y). Although the majority were non-Hispanic white, well educated, and economically well off, substantial numbers of harder-to-recruit women also enrolled (race/ethnicity other than non-Hispanic white: 16%; no college degree: 35%; household income <$50,000: 26%). Although all had a biologic sister with breast cancer, 16.5% had average or lower risk of breast cancer according to the Breast Cancer Risk Assessment Tool (Gail score). Most were postmenopausal (66%), parous with a first full-term pregnancy <30 y of age (79%), never-smokers (56%) with body mass indexes (BMIs) of <29:9 kg=m² (70%). Few (5%) reported any cancer prior to enrollment. CONCLUSIONS: The Sister Study is a unique cohort designed to efficiently study environmental and genetic risk factors for breast cancer. Extensive exposure data over the life-course and baseline specimens provide important opportunities for studying breast cancer and other health outcomes in women. Collaborations are welcome. [ABSTRACT FROM AUTHOR]
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