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Protection by tetramethylpyrazine in acute absolute ethanol-induced gastric lesions.

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  • المؤلفون: Liu CF;Liu CF; Lin CC; Ng LT; Lin SC
  • المصدر:
    Journal of biomedical science [J Biomed Sci] 2002 Sep-Oct; Vol. 9 (5), pp. 395-400.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Print Cited Medium: Print ISSN: 1021-7770 (Print) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2009- : London : BioMed Central
      Original Publication: Basel ; New York : S. Karger Medical and Scientific Publishers, c1994-
    • الموضوع:
      Ethanol/*toxicity ; Gastric Mucosa/*drug effects ; Pyrazines/*therapeutic use; Animals ; Cytochrome c Group/metabolism ; Gastric Mucosa/enzymology ; Gastric Mucosa/injuries ; Lipid Peroxidation ; Male ; Rats ; Rats, Wistar
    • نبذة مختصرة :
      Acute oral administration of absolute ethanol (1.0 ml/kg) to fasting rats produced extensive necrosis of the gastric mucosa within 1 h. Pretreatment 30 min before administration of ethanol with oral tetramethylpyrazine (TMP) prevented this necrosis. Gross examination of the gastric mucosa of rats that received TMP showed fewer gastric lesions than that of rats who did not receive TMP. TMP pretreatment in rats exhibited superoxide scavenging activity in absolute ethanol-induced lipid peroxidation in gastric mucosal homogenates. TMP added in vitro to gastric homogenates made from control rats also showed scavenging activity. We conclude that the gastric protective mechanism of TMP could be attributed, at least in part, to its ability to inhibit lipid peroxidation and hence indirectly protect the gastric mucosa from oxidative stress.
      (Copyright 2002 National Science Council, ROC and S. Karger AG, Basel)
    • الرقم المعرف:
      0 (Cytochrome c Group)
      0 (Pyrazines)
      3K9958V90M (Ethanol)
      V80F4IA5XG (tetramethylpyrazine)
    • الموضوع:
      Date Created: 20020910 Date Completed: 20030212 Latest Revision: 20190607
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1007/BF02256532
    • الرقم المعرف:
      12218353