Point mutation in the alpha helix of the HLA-C alpha2 domain generates a novel HLA-C allele,HLA-Cw*0106, in a Han Chinese individual in Taiwan.

Publisher: Wiley Blackwell Country of Publication: England NLM ID: 0331072 Publication Model: Print Cited Medium: Print ISSN: 0001-2815 (Print) Linking ISSN: 00012815 NLM ISO Abbreviation: Tissue Antigens Subsets: MEDLINE

Publication: <2015>: [Oxford] : Wiley Blackwell
Original Publication: 1971- : Copenhagen, Munksgaard.

Point Mutation*; Asian People/*genetics ; HLA-C Antigens/*chemistry ; HLA-C Antigens/*genetics; Base Sequence ; Humans ; Molecular Sequence Data ; Protein Structure, Secondary ; Taiwan

We report herein the identification of a new HLA-C allele using sequence-based typing (SBT). This novel allele, HLA-Cw*0106, was found in a Han Chinese individual from Taiwan. This individual was typed using SBT as having a class I HLA genotype of HLA-A*0206/0207, HLA-B*4601/5601, and HLA-Cw*0102/0106. This new allele differs from HLA-Cw*0102 in one of the nucleotides of the polymorphic exon 3 at codon 152 (GAG-->GTG; E152V). This residue is located in the alpha helix of the HLA-C alpha2 domain and may have the potential to affect the binding of HLA-C molecules with antigenic peptides and/or the interactions with the T cell receptor. This new allele was detected in a few individuals of Han Chinese in Taiwan, but has not yet been observed in the aboriginal populations in Taiwan.

GENBANK AJ418708; AJ418709

0 (HLA-C Antigens)
0 (HLA-C*01:06 antigen)

Date Created: 20020730 Date Completed: 20030303 Latest Revision: 20221207

20250114

10.1034/j.1399-0039.2002.590514.x

12144631