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Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor.
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- المؤلفون: Mi, Guiyun1; Liu, Shuai1; Zhang, Jian2; Liang, Huichun1; Gao, Yunyun3; Li, Nuomin1; Yu, Boyang2; Yang, Hongju1 ; Yang, Zheng1
- المصدر:
PLoS ONE. 1/13/2017, Vol. 12 Issue 1, p1-13. 13p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Tetrahydroprotoberberines (THPBs) are isoquinoline alkaloids isolated from the Chinese herb Corydalis yanhusuo. In the present study, we performed competitive binding assays to examine the binding of l-THBr to neurotransmitter receptors known to be involved in sedation, hypnosis and anxiety. Our results show that l-THBr does not interact with GABAergic receptors but has binding affinities for dopamine and serotonin receptors. In addition, cAMP and [35S]GTPγS assays were used to determine the agonist or antagonist properties of l-THBr at dopamine (D1, D2) or serotonin (5-HT) receptors. Our results show that l-THBr displays D1 and D2 antagonist and 5-HT1A agonist properties. Moreover, l-THBr-treated rodents exhibit anxiolytic-like effects in the light/dark box and elevated plus-maze tests, and the anxiolytic effect of l-THBr can be reduced by WAY-100635, a selective 5-HT1A receptor antagonist. Our results suggest that l-THBr may produce potent anxiolytic-like effects mainly through serotonin receptors. [ABSTRACT FROM AUTHOR]
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