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Catecholaminergic projections onto spinal neurons destined to the pelvis including the penis in rat.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9007383 Publication Model: Print Cited Medium: Print ISSN: 0955-9930 (Print) Linking ISSN: 09559930 NLM ISO Abbreviation: Int J Impot Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: Basingstoke : Nature Publishing Group
      Original Publication: London, UK : Smith-Gordon, [1989-
    • الموضوع:
      Epinephrine/*physiology ; Neurons/*physiology ; Norepinephrine/*physiology ; Pelvis/*innervation ; Penis/*innervation ; Spinal Cord/*physiology ; Synaptic Transmission/*physiology; Animals ; Dopamine beta-Hydroxylase/metabolism ; Herpesvirus 1, Suid ; Male ; Nerve Fibers/physiology ; Nerve Fibers/ultrastructure ; Nervous System Physiological Phenomena ; Neurons/pathology ; Neurons/virology ; Phenylethanolamine N-Methyltransferase/metabolism ; Pseudorabies/pathology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/ultrastructure ; Spinal Cord/virology
    • نبذة مختصرة :
      In rats, the spinal cord contains proerectile autonomic motoneurons destined to the penile tissue and its vasculature, and somatic motoneurons destined to the perineal striated muscles. It receives dense catecholaminergic projections issued from the medulla and pons. In adult male rats, we evidenced the catecholaminergic innervation of spinal neurons controlling lower urogenital tissues and regulating penile erection. We combined retrograde tracing techniques and immunohistochemistry against synthetic enzymes of noradrenaline and adrenaline. Both sympathetic and parasympathetic preganglionic neurons, labeled from the major pelvic ganglion or from the corpus cavernosum, were apposed by catecholaminergic immunoreactive fibers. Motoneurons, retrogradely labeled from the striated muscles, were also apposed by catecholaminergic immunoreactive fibers. Synapses between these motoneurons and fibers were suggested by confocal microscopy and confirmed by electron microscopy in some cases. The results reinforce the hypothesis of a catecholaminergic control of autonomic and somatic motoneurons regulating penile erection at the spinal level.
    • الرقم المعرف:
      EC 1.14.17.1 (Dopamine beta-Hydroxylase)
      EC 2.1.1.28 (Phenylethanolamine N-Methyltransferase)
      X4W3ENH1CV (Norepinephrine)
      YKH834O4BH (Epinephrine)
    • الموضوع:
      Date Created: 20020612 Date Completed: 20021204 Latest Revision: 20131121
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1038/sj.ijir.3900809
    • الرقم المعرف:
      12058242