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The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.
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- معلومة اضافية
- المصدر:
Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Print ISSN: 1061-4036 (Print) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
- بيانات النشر:
Original Publication: New York, NY : Nature Pub. Co., c1992-
- الموضوع:
- نبذة مختصرة :
Deletions of the AZFc (azoospermia factor c) region of the Y chromosome are the most common known cause of spermatogenic failure. We determined the complete nucleotide sequence of AZFc by identifying and distinguishing between near-identical amplicons (massive repeat units) using an iterative mapping-sequencing process. A complex of three palindromes, the largest spanning 3 Mb with 99.97% identity between its arms, encompasses the AZFc region. The palindromes are constructed from six distinct families of amplicons, with unit lengths of 115-678 kb, and may have resulted from tandem duplication and inversion during primate evolution. The palindromic complex contains 11 families of transcription units, all expressed in testis. Deletions of AZFc that cause infertility are remarkably uniform, spanning a 3.5-Mb segment and bounded by 229-kb direct repeats that probably served as substrates for homologous recombination.
- Comments:
Comment in: Nat Genet. 2001 Nov;29(3):243-4. (PMID: 11687786)
- Molecular Sequence:
GENBANK AC010139; AC010724; AC010725; AC010727; AC011295; AC015973; AF332228; AF332229; AF332230; AF332231; AF332236; AF332237; AF334526; AF334546; G34986; G38343; G38345; G38349; G63909; G67162; G67163; G67164; G67165; G67166; G67167; G67168; G67169; G67170; G67171; G67175
- الرقم المعرف:
0 (DAZ1 protein, human)
0 (Deleted in Azoospermia 1 Protein)
0 (RNA-Binding Proteins)
- الموضوع:
Date Created: 20011101 Date Completed: 20011207 Latest Revision: 20220331
- الموضوع:
20231215
- الرقم المعرف:
10.1038/ng757
- الرقم المعرف:
11687796
No Comments.