Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Pre-treatment affinity for LJP 394 influences pharmacodynamic response in lupus patients.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print Cited Medium: Print ISSN: 0961-2033 (Print) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : SAGE Publications
      Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991-
    • الموضوع:
      Lupus Nephritis/*drug therapy ; Oligonucleotides/*administration & dosage ; Oligonucleotides/*immunology; Antibodies, Antinuclear/blood ; Antibody Affinity ; Binding, Competitive/drug effects ; Binding, Competitive/immunology ; Cohort Studies ; DNA/immunology ; Double-Blind Method ; Humans ; Immunoglobulin G/blood ; Iodine Radioisotopes ; Lupus Nephritis/immunology
    • نبذة مختصرة :
      Five prospective clinical studies in lupus patients have shown that LJP 394 can reduce circulating anti-dsDNA antibody levels without causing generalized immunosuppression. The compound is currently being evaluated in a phase III clinical trial for the prevention of renal flares in patients with high-affinity antibodies to LJP 394 and a history of lupus nephritis. The current study analyzed the affinity of patient IgG for LJP 394 prior to and following 4 months of treatment with LJP 394 to determine if pretreatment affinity influenced pharmacodynamic response. Patient serum samples from a multicenter, double-blind, placebo-controlled trial were evaluated prior to and following 4 months of weekly, biweekly or monthly treatment with placebo (n = 9) or weekly treatment with 10 mg LJP 394 (n = 6) or 50 mg LJP 394 (n = 4). After treatment there was a dose-dependent reduction in affinity in the 10 mg/week and 50 mg/week groups (P < 0.05 and P < 0.01, respectively), whereas the placebo group was unchanged. This study demonstrates that weekly treatment with LJP 394 produces a dose-dependent reduction in titer-weighted average affinity. These results suggest it may be possible to use an affinity assay to define prospectively patients that are most likely to exhibit the desired pharmacodynamic response to LJP 394.
    • Comments:
      Comment in: Lupus. 2001;10(8):521-2. (PMID: 11530991)
    • الرقم المعرف:
      0 (Antibodies, Antinuclear)
      0 (Immunoglobulin G)
      0 (Iodine Radioisotopes)
      0 (Oligonucleotides)
      9007-49-2 (DNA)
      P3UVQ22SHK (abetimus)
    • الموضوع:
      Date Created: 20010904 Date Completed: 20020206 Latest Revision: 20171116
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1191/096120301701549642
    • الرقم المعرف:
      11530993