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Specificity and function of activating Ly-49 receptors.

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  • المؤلفون: Kane KP;Kane KP; Silver ET; Hazes B
  • المصدر:
    Immunological reviews [Immunol Rev] 2001 Jun; Vol. 181, pp. 104-14.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print Cited Medium: Print ISSN: 0105-2896 (Print) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2002-> : Oxford : Blackwell
      Original Publication: Copenhagen, Munksgaard.
    • الموضوع:
      Antigens, Ly*; Killer Cells, Natural/*immunology ; Membrane Glycoproteins/*metabolism; Animals ; Binding Sites ; Gene Expression ; Genetic Variation ; Histocompatibility Antigens Class I/metabolism ; Humans ; Lectins, C-Type ; Ligands ; Membrane Glycoproteins/chemistry ; Membrane Glycoproteins/genetics ; Mice ; Models, Biological ; Models, Molecular ; Multigene Family ; Phylogeny ; Receptors, NK Cell Lectin-Like ; Signal Transduction
    • نبذة مختصرة :
      Inhibitory Ly-49 receptors allow murine natural killer (NK) cells to kill cells with aberrant class I MHC expression while sparing normal cells. This is accomplished by their recognition of specific class I MHC products and prevention of NK-cell lysis of cells that present a normal repertoire of class I MHC ligands--"the missing self hypothesis". However, Ly-49 receptors that lack the cytoplasmic immunoreceptor tyrosine-based inhibitory motif, which is required for inhibition of killing, have also been described. These receptors were found to stimulate NK killing and are therefore referred to as activating Ly-49 receptors. Interestingly, the activating receptors have class I MHC-binding domains that are nearly indistinguishable from those of the inhibiting receptors, and binding to class I MHC has now been demonstrated for three activating receptors. Presently, there is no defined physiological role for activating Ly-49 receptors. Here we present an overview of current knowledge regarding the diversity, structure and function of activating Ly-49 receptors with a focus on class I MHC specificity, and we discuss their potential role(s) in natural resistance.
    • Number of References:
      71
    • الرقم المعرف:
      0 (Antigens, Ly)
      0 (Histocompatibility Antigens Class I)
      0 (Lectins, C-Type)
      0 (Ligands)
      0 (Membrane Glycoproteins)
      0 (Receptors, NK Cell Lectin-Like)
    • الموضوع:
      Date Created: 20010822 Date Completed: 20020219 Latest Revision: 20190915
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1034/j.1600-065x.2001.1810108.x
    • الرقم المعرف:
      11513132