UHPLC or Core-Shell Which is the Winner?

Commercial UHPLC technology burst onto the scene in 2004. It was the new technology that was going to move chromatography forward, however was it really new? The sceptic in me says no, we had moved from 5μm particles to 3μm particles 10-15 years previously, moving down to the next particle size, i.e. sub 2μm was the next logical step and this is what UHPLC essentially was. An LC system with extreme low dead volume and 'bolt on high pressure'. I say 'bolt on high pressure' because what does the pressure dofor our chromatography, it doesn't give us more efficiency, resolution, selectivity or speed, it allows us to use smaller particles, which then does give us greater efficiency and subsequent speed and resolution. [ABSTRACT FROM AUTHOR]