Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Drosophila Proteins* ; Eye Proteins* ; Light* ; Photoreceptor Cells, Invertebrate*; Circadian Rhythm/*physiology ; Melatonin/*metabolism ; Photoreceptor Cells, Vertebrate/*physiology ; Pineal Gland/*metabolism ; Retina/*physiology; Animals ; Biological Clocks/physiology ; Cryptochromes ; Darkness ; Flavoproteins/genetics ; Flavoproteins/physiology ; Light Signal Transduction ; Mice ; Mice, Inbred C3H ; Mice, Transgenic ; Receptors, G-Protein-Coupled ; Retina/cytology ; Retinal Ganglion Cells/physiology ; Retinal Pigments/genetics ; Retinal Pigments/physiology

In mammals, ocular photoreceptors mediate an acute inhibition of pineal melatonin by light. The effect of rod and cone loss on this response was assessed by combining the rd mutation with a transgenic ablation of cones (cl) to produce mice lacking both photoreceptor classes. Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers. These data indicate that mammals have additional ocular photoreceptors that they use in the regulation of temporal physiology.

Comment in: Science. 1999 Apr 16;284(5413):421-2. (PMID: 10232983)

0 (Cryptochromes)
0 (Drosophila Proteins)
0 (Eye Proteins)
0 (Flavoproteins)
0 (Receptors, G-Protein-Coupled)
0 (Retinal Pigments)
0 (cry protein, Drosophila)
JL5DK93RCL (Melatonin)

Date Created: 19990416 Date Completed: 19990504 Latest Revision: 20220311

20231215

10.1126/science.284.5413.505

10205062