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Valproic Acid: Pharmacology, Mechanisms of Action and Clinical Implications

• Authors : Boucher, Alexis

Subjects: Valproic acidMEDICAL / Psychiatry / Psychopharmacology; MEDICAL / Pain Management

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Fatal hyperammonemic encephalopathy triggered by valproic acid in adult-onset type II citrullinemia: A diagnostic pitfall.

• Authors : Kim, Young-Soo^1,2,3 ; Kim, Minjung^1,3; Kim, Do-Hyung⁴

• Source: Neurology Asia. 2026, Vol. 31 Issue 2, p853-857. 5p.

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Hepatic adverse effects of valproic acid: Management strategies.

• Authors : Bouaziz, Imen¹ (AUTHOR) ; Atheymen, Rim¹ (AUTHOR); Sahnoun, Rym¹ (AUTHOR)

• Source: Indian Journal of Pharmacology. May/Jun2026, Vol. 58 Issue 3, p266-271. 6p.

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Association Between Duration of Valproic Acid Therapy, Serum calcium Levels, and Nutritional Status in Children with Epilepsy.

• Authors : Sumartiya, Sherly¹; Urfianty¹; Anggriani, Hadia^1,2

• Source: Journal of Chemical Health Risks. 2026, Vol. 16 Issue 2, p2069-2076. 8p.

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Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells.

• Authors : Kandhavelu, Jeyalakshmi¹ (AUTHOR); Subramanian, Kumar¹ (AUTHOR); Moodley, Natanya¹ (AUTHOR)

• Source: PLoS ONE. 6/1/2026, Vol. 21 Issue 6, p1-18. 18p.

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Valproic acid induced oxidative brain injury in rats: Protective effect of edaravone.

• Authors : ÇAKMAK, Neziha HACIHASANOĞLU¹ ; YANARDAG, Refiye²

• Source: Veterinary Journal of Ankara University / Ankara Universitesi Veteriner Fakultesi Dergisi. 2026, Vol. 73 Issue 2, p185-193. 9p.

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Protective effect of alpha lipoic acid against oxidative damage caused by valproic acid on lung tissue in rats.

• Authors : SHIRINOV, Royal¹; TURKYILMAZ MUTLU, Ismet Burcu¹; DAGSUYU, Eda¹

• Source: Veterinary Journal of Ankara University / Ankara Universitesi Veteriner Fakultesi Dergisi. 2026, Vol. 73 Issue 2, p177-184. 8p.

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A QSP Model of Valproic Acid Toxicity in Pediatric and Adult Populations: Implications for Formulation Selection and L‐Carnitine Supplementation.

• Authors : Schiavo, Alejandra^1,2 (AUTHOR); Maldonado, Cecilia¹ (AUTHOR); Vázquez, Marta¹ (AUTHOR)

• Source: CPT: Pharmacometrics & Systems Pharmacology. Feb2026, Vol. 15 Issue 2, p1-11. 11p.

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Expanded Hemodialysis Using a Medium Cut-Off Dialyzer for Severe Valproic Acid Poisoning: A Case Report with Real-Time Therapeutic Drug Monitoring.

• Authors : Rodríguez Tudero, Celia^1,2 (AUTHOR); Chandu Nanwani, Avinash^2,3 (AUTHOR); Jiménez Mayor, Elena^3,4 (AUTHOR)

• Source: Journal of Clinical Medicine. Mar2026, Vol. 15 Issue 6, p2220. 14p.

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Seizure freedom on subtherapeutic levels of valproic acid.

• Authors : Basheikh, Mazen A.¹ (AUTHOR)

• Source: Journal of Family Medicine & Primary Care. Feb2026, Vol. 15 Issue 2, p996-999. 4p.

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