Therapeutic drug for lipid-peroxidation-induced diseases and screening method for therapeutic drugs for lipid-peroxidation-induced diseases

11519,893

16/628446

July 05, 2018

The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions. [chemical expression included]

Yamada, Ken-ichi (Fukuoka, JP); FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Osaka, JP)

Yamada, Ken-Ichi (Fukuoka, JP), FUSO PHARMACEUTICAL INDUSTRIES, LTD. (Osaka, JP)

1. An assay kit for detecting lipid peroxidation inhibitory activity of a test compound, comprising: a compound represented by formula (I): [chemical expression included] a liposome, and at least one compound selected from the group consisting of 2,2′-azobis(2-aminopropane) dihydrochloride and a divalent iron ion source material in a buffer.

2. The assay kit according to claim 1 , wherein the divalent iron ion source material is iron(II) sulfate.

3. The assay kit according to claim 1 , comprising a package insert showing an activity value of a compound having lipid peroxidation inhibitory activity.

4. An assay kit comprising any two or more of the assay kits according to claim 1 .

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