Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Methods of treatment of menopause and perimenopause using eszopiclone

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Publication Date:
    December 16, 2008
  • معلومة اضافية
    • Patent Number:
      7,465,729
    • Appl. No:
      11/099155
    • Application Filed:
      April 05, 2005
    • نبذة مختصرة :
      The invention relates to the use of eszopiclone for the treatment of symptoms accompanying perimenopause or menopause.
    • Inventors:
      Wessel, Thomas (Lenox, MA, US); Caron, Judy (Westwood, MA, US)
    • Assignees:
      Sepracor Inc. (Marlborough, MA, US)
    • Claim:
      1. A method for treating hot flashes accompanying perimenopause or menopause in a patient having perimenopause or menopause symptoms, the method comprising administering to the patient having perimenopause or menopause symptoms a therapeutically effective amount of eszopiclone having an enantiomeric excess greater than ninety percent.
    • Claim:
      2. A method according to claim 1 wherein said eszopiclone is administered parenterally, transdermally, orally or by inhalation.
    • Claim:
      3. A method according to claim 1 wherein said eszopiclone is administered in an amount of 0.5 mg to 15 mg per day.
    • Claim:
      4. A method according to claim 3 wherein said eszopiclone is administered in an amount chosen from of 0.5 mg, 1.0 mg, 2.0 mg and 3.0 mg per dosage.
    • Current U.S. Class:
      514/249
    • Patent References Cited:
      5786357 July 1998 Young et al.
      6153216 November 2000 Cordes et al.
      WO 93/10787 June 1993












































    • Other References:
      Soares et al. Six-month efficacy study of eszopiclone in perimenopausal and postmenopausal women with chronic insomnia. Obstetrics and Gynecology, Apr. 1, 2004, vol. 103, Suppl. No. 4 p. 102. cited by examiner
      Furukawa et al., “Antidepressant and benzodiazepine for major depression,” John Wiley & Sons, Ltd., (1), 1-43, (2005). cited by other
      Cohen, et al.; “Sleep in chronic pain: problems and treatments,” Int'l Review of Psychiatry; vol. 12, No. 2: pp.115-126 (2000). cited by other
      Drewes et al.; “Zopiclione as Night Medication in Rheumatoid Arthritis,” Scand J Rheumatol; 27: 180-7 (1998). cited by other
      Affleck G, Urrows S, Tennen H, Higgins P, Abeles M, Seqeuntial daily relations of sleep, pain intensity, and attention to pain among women with fibromyalgia pain 68:363-368 (1996). cited by other
      Asnis GM, Chakrabarty A, DuBoff EA, et al; Zolpidem for persistent insomnia in SSRI-treated depressed patients J Clin Psychiastry 60:668-676 (1999). cited by other
      Barone P, Amboni M., Vitale C, Bonavita V., Treatment of nocturnal disturbance and excessive daytime sleepiness in Parkinson's disease, Neurology 63:S35-S38 (2004). cited by other
      Benca RM, Ancoli-Israel A, Moldofsky H., Special considerations in insomnia diagnosis and management: Depressed, elderly, and chronic pain populations J Clin Psychiatry 65 (Suppl 8):26-35 (2004). cited by other
      Billiard M, Bentley A. Is insomnia best categorized as a symptom or a disease? Sleep Medicine 5(Suppl 1):S35-S40 (2004). cited by other
      Bliwise DL, Sleep disorders in Alzheimer's disease and other dementias, Clin. Cornerstone 6 Suppl 1A:S16-28 (2004). cited by other
      Bloom BJ, Owens JA, McGuinn M, Nobile C., Shaeffer L, Alario AJ, Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritis; J Rheumatol 29:169-173 (2002). cited by other
      Bourguignon C, Labyak SE, Taibi D, Investigating sleep disturbances in adults with rheumatoid arthritis, Holist Nurs Pract 17:241-249 (2003). cited by other
      Breslau N, Roth T, Rosenthal L, Andreski P, Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults, Biol Psychiatry 39:411-418 (1996). cited by other
      Chang PP, Ford DE, Mead LA et al., Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study, Am J Epidemiol. 146:105-114 (1997). cited by other
      Dorsey CM, Lee KA, Scharf MB Effect of zolpidem on sleep in women with perimenopausal and postmenopausal insomnia: A 4-week, randomized, multicenter, double-blind placebo-controlled study Clin Ther 16:873-897 (2004). cited by other
      Drewes AM Pain and sleep disturbances with special reference to fibromyalgia and rheumatoid arthritis, Rheumatology (Oxford) 38:1035-1038 (1999). cited by other
      Drewes AM, Nielsen KD, Hansen B, Taagholt SJ, Bjerregard K, Svendsen L, A longitudinal study of clinical symptoms and sleep parameters in rheumatoid arthritis, Rheumatology (Oxford) 39:1287-1289 (2000). cited by other
      Drewes AM, Svendsen L, Taagholt, Bjerregard k, Nielsen KD, Hansen B, Sleep in rheumatoid arthritis: a comparison with healthy subjects and studies of sleep/wake interactions, Br J Rheumatol 37:71-81 (1998). cited by other
      Ford DE, Kamerow DB, Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?, JAMA 262:1479-1484 (1989). cited by other
      Ford DE, Cooper-Patrick L, Sleep disturbances and modd disorders:an epidemiologic perspective, Depress Anxiety 14:3-6 (2001). cited by other
      Gillin JC, Are sleep disturbances risk factors for anxiety, depressive and addictive disorders? Acta Psychiatr Scand Suppl. 393:39-43 (1998). cited by other
      Hyyppa MT, Kronholm E, Quality of sleep and chronic illnesses J Clin Epidemiol 42:633-638 (1989). cited by other
      Katz DA, McHorney CA. Clinical correlates of insomnia in patients with chronic illness. Arch Intern Med 158:1099-1107 (1998). cited by other
      Koren D, Arnon I, Lavie P, et al. Sleep complaints as early predictors of posttraumatic stress disorder: a 1-year prospective study of injured survivors of motor vehicle accidents. Am J Psychiatry 159:855-857 (2002). cited by other
      Livingston G, Blizard B, Mann A, Does sleep disturbance predict depression in elderly people? A study in inner London, Br J Gen Pract. 43:445-448 (1993). cited by other
      Londborg PD, Smith WT, Glaudin V, Painter JR. Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression., J. Affect Disord. 61:73-79 (2000). cited by other
      Mahowald MW, Mahowald ML, Bundlie SR, Ytterberg SR, Sleep fragmentation in rheumatoid arthritis Arthritis Rheum 32:974-983 (1989). cited by other
      McCall MV, A psychiatric perspective on insomnia, J Clin Psychiatry 62(Suppl 10):27-32 (2001). cited by other
      McCurry SM, Ancoli-Israel S, Sleep dysfunction in Alzheimer's disease and other dementias Curr Treat Options Neurol 5:261-272 (2003). cited by other
      Nierenberg AA, Keefe BR, Leslie VC et al, Residual symptoms in depressed patients who respond acutely to fluoxetine J Clin Psychiatry 60:221-225 (1999). cited by other
      Nolen, WA, Hypnotics as concurrent medication in depression Jrnl of Affective Disorders 28 (1993) 179-188. cited by other
      O'Bryant SE, Palav A, McCaffrey RJ, A review of symptoms commonly associated with menopause: implications for clinical neuropsychologists and other health care providers, Neuropsychol Rev. 13:145-152 (2003). cited by other
      Perlis ML, Giles DE, Buysse DJ, et al. Self-reported sleep disturbance as a prodromal symptom in recurrent depression. J Affect Disord 42:209-212 (1997). cited by other
      Punjabi NM, Shahar E, Redline S, et al, Investigators SHHS, Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study Am J Epidemiol 160:521-530 (2004). cited by other
      Renko, A, Hiltunen L, Laakso M, et al. The relationship of glucose tolerance to sleep disorders and daytime sleepiness Diabetes Res Clin Pract 67:84-91 (2005). cited by other
      Rickels K, Schweizer E, Case WG, DeMartinis N, Greenblatt DJ, Mandos LA, Espana FG. Nefazodone in major depression: adjunctive benzodiazepine therapy and tolerability, J, Clin Psychopharmacol 18:145-153 (1998). cited by other
      Riemann D, Voderholzer U, Primary Insomnia: a risk factor to develop depression, J Affect Disord 76:255-259 (2003). cited by other
      Shaver JL, Women and sleep, Nurse Clin North Am. 37:707-718 (2002). cited by other
      Smith WT, Londborg PD, Glaudin V, Painter JR. Shortterm augmentation of fluoxetine with clonazepam in the treatment of depression: a doub-blind study, Am J. Psychiatry 155:1339-1345 (1998). cited by other
      Smith WT, Londborg PD, Glaudin V, Painter JR. Summit Research Network. Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression?, J Affect Disord 70:251-259 (2002). cited by other
      Thorpy MJ, Sleep disorders in Parkinson's disease Clin Cornerstone 6 Suppl 1A:S7-15 (2004). cited by other
      Tishler M, Barak Y, Paran D, Yaron M., Sleep disturbances, fibromyalgia and primary Sjogren's syndrome Clin Exp Rheumatol 15:71-74 (1997). cited by other
      Van Cauter E, Polonsky KS, Scheen AJ, Roles of circadian rhythmicity and sleep in human glucose regulation Endocr Rev 18:716-738 (1997). cited by other
      Walsh JK, Clinical and socioeconomic correlates of insomnia; J Clin Psychiatry 65 (Suppl 8):13-19 (2004). cited by other
      Zamir G, Press J, Tal A, Tarasiuk A, Sleep fragmentation in children with juvenile rheumatoid arthritis J Rheumatol 25:1191-1197 (1998). cited by other
    • Primary Examiner:
      Kim, Jennifer Myong
    • Attorney, Agent or Firm:
      Heslin Rothenberg Farley & Mesiti P.C.
    • الرقم المعرف:
      edspgr.07465729