Effectiveness Of Vildagliptin Versus Teneligliptin As An Add On Therapy In Type 2 Diabetes Mellitus Patients

Background: Diabetes is a chronic condition that develops when the body is unable to effectively utilise the insulin that the pancreas generates, or when the organ is unable to produce insulin at all. Innovative therapeutic agents are required to further advance the management of type 2 diabetes mellitus, a condition that is progressing and common. DPP-4 inhibitors offer unique advantages such as low risk of hypoglycaemia, weight neutrality, and oral administration , making them valuable options in the treatment of type 2 diabetes. Overall, their favourable safety profile and convenient once-daily dosing make DPP-4 inhibitors a valuable addition to the treatment options. In order to effectively manage type 2 diabetes, DPP-4 inhibitors are a useful complement to the therapeutic alternatives.DPP-4 inhibitors are particularly effective at targeting postprandial (after-meal) hyperglycaemia, which is a significant contributor to overall blood sugar levels in patients with type 2 diabetes. Aim and Objectives: To assess the effectiveness of vildagliptin versus teneligliptin as an add on therapy in type 2 diabetes patients, To compare the effectiveness on the HbA1c reduction , To assess the safety profile and tolerability Method: A Prospective observational study was conducted in the General Medicine department, PSG Hospital for a duration of 1 year. A total of 80 patients were selected based on the inclusion and exclusion criteria. The patients were divided into two groups Group A and Group B, where Group A were receiving the medication vildagliptin and consist a total number of 40patients where Group B where receiving the medication Teneligliptin which consist a total number of 40 patients. And both the groups were followed up to 3 months to find out the reduction difference in the HbA1c, FBS, and PPBS. Both the drugs were found to be effective but after the 3 months follow up Group B(Teneligliptin) has shown a significant reduction in the HbA1C, and FBS where as a significant reduction in the PPBS was found in the ...