Palladium-Catalyzed C–H Arylation and Azetidination of Pentacyclic Triterpenoids

Synthetic protocols for site-selective palladium-catalyzed C–H arylation and azetidination of pentacyclic triterpenoids have been developed. Betulin, oleanolic, and ursolic acids were converted into primary amines C(28)-NH 2 that were further transformed into the corresponding picolinamides. The latter was found to be a suitable directing group for triterpenoid C( sp 3 )-H (het)arylation with iodo(het)arenes in the presence of Pd(OAc) 2 /CuBr 2 /CsOAc system. C( sp 3 )-H (het)arylation provided yields from 29 to 83%, and the C(22)/C(16) selectivity from 9:1 in the lupane (betulin) series to 19:1 in the oleane and ursane series. The highest isolated yields of C( sp 3 )-H arylated products were achieved with iodoarenes bearing electron-donating groups, but the use of electron-deficient iodoarenes gave a significant proportion of N -picolinoyl azetidine side product. The latter were obtained with good selectivity as major products when 1-iodo-4-nitrobenzene was used as an additive. C( sp 3 )-H arylation revealed C(22)-selectivity in all tested triterpenoid series; however, the azetidination occurred at C(22) in lupane (betulin) series and at C(16) in oleane series. C( sp 3 )-H (het)arylation and azetidination is a new entry in the derivatization of natural triterpenoids and can be regarded as a useful tool for further exploration in terms of medicinal chemistry.