نبذة مختصرة : Sex differences are known to influence both micronutrient metabolism and cardiometabolic health outcomes. However, the extent to which these sex-specific factors interact, particularly in the relationship between micronutrient status and cardiometabolic risk, remains insufficiently understood. The present study aimed to investigate sex differences in health and micronutrient status, and their association with blood lipids, body mass index, and body weight. The final sample size included 488 Austrian adults (median age: 38 years; comprising 256 males and 232 females) who successfully met the inclusion criteria. Blood analyses were conducted to measure whole-blood micronutrients and serum levels of various cardiometabolic health biomarkers, including blood lipids. Micronutrient status (including deficiencies and excesses) was calculated using sex-specific reference ranges. There were significant differences between males and females for most (19 out of 28) blood biomarkers of cardiometabolic health (p < 0.05), with females generally showing a healthier cardiometabolic profile. Significant sex differences were also observed in the adjusted values of three micronutrients: copper was higher in females, while iron and vitamin B12 were higher in males (p < 0.05). Sex differences in micronutrient status indicated a higher prevalence of iron deficiency and copper excess among females (p < 0.05). Different patterns were observed between males and females in the association of blood lipids and body composition with micronutrients and demographic factors. These findings highlight the importance of individualized approaches in preventive and therapeutic health interventions based on differences between males and females.
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