The effect of TGF- β blocking (+Ab) and the combined therapy (+Ab+DNase I) on tumor cell invasion.

(A) The (relative) population of migrating tumor cells for various growth rates ( r ∈ [1.2, 1.5]) and injection rates (λ A ∈ [0, 10]) of the TGF- β antibody. When TGF- β activity is inhibited by antibody ( r = 1.5), fewer cells (62% reduction) invade the lower chamber. (B) Population of migrating tumor cells when the TGF- β antibody was added in the absence (+Ab-D) and presence (+Ab+D) of DNase I relative to the control (-Ab-D). When proteolytic activity of tumor cells near the membrane is blocked by DNase I, fewer cells (66% reduction) invade the lower chamber in the presence of TGF- β inhibitor.