Schematic of the model construction and evaluation pipeline.

This diagram outlines the procedure for building and validating the predictive model. The workflow starts with paired miRNA-mRNA profiles derived from bulk RNA-seq samples. The mRNA expression data serves as the input for model construction, which generates a predicted miRNA profile. This predicted profile is then compared against the actual miRNA profile from the same samples, which serves as the ground truth. The predictive performance of the model is quantitatively assessed by calculating the Spearman correlation between the predicted and actual miRNA profiles. (PDF)