Activity of the hypothalamic neuropeptide Y increases in adult and decreases in old rats.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Neuropeptide Y*/metabolism ; Aging*/metabolism ; Aging*/physiology ; Hypothalamus*/metabolism ; Hypothalamus*/drug effects ; Rats, Wistar* ; Eating*; Body Weight/drug effects ; Obesity/metabolism ; Arcuate Nucleus of Hypothalamus/metabolism ; Arcuate Nucleus of Hypothalamus/drug effects ; Animals ; Male ; Rats

Middle-aged obesity and aging anorexia with muscle loss (sarcopenia) of old people present public health burden. These alterations may appear both in humans and rodents suggesting the role for regulatory alterations. Previously, we demonstrated that biphasic changes in the weight-reducing (catabolic) effects of neuropeptides of the hypothalamus-adipose tissue axis (e.g. leptin) may contribute to both trends. With regard to the anabolic effects of the hypothalamic neuropeptide Y (NPY) inhibited by leptin, we hypothesized non-linear age-related changes with shifts in the opposite directions. We investigated the orexigenic and hypometabolic effects of intracerebroventricularly administered NPY (hyperphagia induced by NPY injection or changes in food intake, body weight, heart rate, body temperature, locomotor activity during a 7-day NPY infusion), the immunoreactivity and gene expression of NPY in the hypothalamic arcuate nucleus of male Wistar rats of five age groups from young to old. The orexigenic/hypometabolic efficacy and the immunoreactivity of NPY increased in middle-aged animals preceding the peak of adiposity observed in aging rats, then decreased preceding anorexia and weight loss in old rats. These shifts may contribute to the development of both age-related obesity and aging anorexia, sarcopenia, and should be considered in future drug development targeting the NPY system.
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FK124188 National Research, Development and Innovation Fund of Hungary; K138452 National Research, Development and Innovation Fund of Hungary; TKP2021-EGA-16 Thematic Excellence Program 2021 Health Sub-program of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of Pécs University; HUN-REN-TKI14016 Hungarian Research Network; ÁOK_KA_2022_29 Medical School of the University of Pecs, Hungary; ÁOK_KA_2021_37 Medical School of the University of Pecs, Hungary; ÁOK_KA_2019_44 Medical School of the University of Pecs, Hungary; BO/00750/22/5 János Bolyai Research Scholarship of the Hungarian Academy of Sciences; ÚNKP-23-5-PTE-1991 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund; RRF, RRF-2.3.1-21-2022-00011 European Union's Recovery and Resilience Facility; EFOP-3.6.2-16-2017-00006 Human Resources Development Operational Programme Grant of the National Research, Development and Innovation Fund of Hungary

Keywords: Aging anorexia; Metabolism; Obesity

0 (Neuropeptide Y)

Date Created: 20240930 Date Completed: 20241001 Latest Revision: 20241003

20260130

PMC11442438

10.1038/s41598-024-73825-7

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