Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Evaluation of hemorheological parameters as biomarkers of calcium metabolism and insulin resistance in postmenopausal women.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: SAGE Publications Country of Publication: United States NLM ID: 9709206 Publication Model: Print Cited Medium: Internet ISSN: 1875-8622 (Electronic) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2025- : [Thousand Oaks, CA] : SAGE Publications
      Original Publication: Amsterdam ; Washington, DC : IOS Press, c1997-
    • الموضوع:
      Biomarkers/*blood ; Calcium/*metabolism ; Cardiovascular Diseases/*blood ; Hemorheology/*genetics ; Insulin Resistance/*genetics; Aged ; Erythrocyte Deformability ; Female ; Humans ; Middle Aged ; Postmenopause
    • نبذة مختصرة :
      Background: Calcium, vitamin D and insulin resistance are linked to osteoporosis and cardiovascular disease in menopause.
      Objective: Determine if hemorheological parameters related to blood viscosity in microcirculation are linked to calcium metabolism and insulin resistance in menopause.
      Methods: 25-Hydroxyvitamin D (25(OH)D)), 1, 25-dihydroxyvitamin D3 (1, 25(OH)2D), parathyroid hormone, ionized calcium, glucose, insulin and hemoglobin A1c were measured in blood from 43 volunteers. Red blood cells (RBC) aggregation, RBC deformability and whole blood viscosity were also performed.
      Results: 25(OH)D showed a positive correlation with RBC deformability 0.60 Pa. Subjects with 25(OH)D≤29.00 ng/mL had lower RBC deformability 0.60 Pa, and higher RBC aggregation and higher HOMA-IR. Ionized calcium showed a negative correlation with RBC aggregation. Subjects with ionized calcium ≤1.24 mmol/L showed higher RBC aggregation. There was a positive correlation between HOMA-IR and RBC aggregation and HOMA-IR showed a negative correlation with RBC deformability 0.30 Pa. Subjects with HOMA-IR <1.80 showed lower RBC aggregation and higher RBC deformability at 0.30 Pa, 0.60 Pa, 1.20 Pa, 3.0 Pa and 6.0 Pa.
      Conclusion: Low 25(OH)D, low ionized calcium and high HOMA-IR are related to impaired hemorheology in menopause. RBC aggregation and deformability can be used as biomarkers of calcium metabolism and insulin resistance in menopause.
    • Contributed Indexing:
      Keywords: Hemorheology; calcium metabolism; cardiovascular diseases; insulin resistance; osteoporosis; vitamin D
    • الرقم المعرف:
      0 (Biomarkers)
      SY7Q814VUP (Calcium)
    • الموضوع:
      Date Created: 20210102 Date Completed: 20210521 Latest Revision: 20210521
    • الموضوع:
      20260130
    • الرقم المعرف:
      10.3233/CH-200956
    • الرقم المعرف:
      33386795