Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Reference Ranges and Association of Age and Lifestyle Characteristics with Testosterone, Sex Hormone Binding Globulin, and Luteinizing Hormone among 1166 Western Chinese Men.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Life Style*; Blood Chemical Analysis/*standards ; Luteinizing Hormone/*blood ; Sex Hormone-Binding Globulin/*analysis ; Testosterone/*blood; Adult ; Age Factors ; Aged ; Aged, 80 and over ; China ; Humans ; Male ; Middle Aged ; Reference Values ; Young Adult
    • نبذة مختصرة :
      Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their correlates among Western Chinese men. We completed a population-based, cross-sectional study including 227 young adults (YA) (20-39 years) and 939 older adults (OA) (40-89 years). We measured TT, sex-hormone binding globulin (SHBG), luteinizing hormone (LH), testosterone secreting index (TSI), and calculated free testosterone (cFT). Reference ranges for this population were determined using average YA concentrations. Multivariable regression models were used to predict hormone concentrations adjusting for age, waist-to-height ratio (WHR), marital status, education, occupation, smoking, alcohol, blood glucose, and blood pressure. Among OA, 3.8% had low TT, 15.2% had low cFT, 26.3% had low TSI, 21.6% had high SHBG, and 6.1% had high LH. Average cFT was significantly lower in OA (0.30 nmol/L; standard deviation (SD): 0.09) versus YA (0.37; SD: 0.11) but TT was not different in OA (16.82 nmol/L; SD: 4.80) versus YA (16.88; SD: 5.29). In adjusted models increasing age was significantly associated with increased SHBG or LH, and decreased cFT or TSI; however, TT was not significantly associated with age (β = 0.02 nmol/L; 95% confidence interval (CI): -0.01, 0.04). Higher WHR was associated with significantly decreased TT, SHBG, TSI, and LH. The only variable significantly related to cFT was age (β = -0.0033; 95% CI:-0.0037, -0.0028); suggesting that cFT measurements would not be confounded by other lifestyle factors. In conclusion, cFT, but not TT, varies with age in this population, suggesting cFT may be a better potential marker for age-related androgen deficiency than TT among Western Chinese men.
    • نبذة مختصرة :
      The authors have declared that no competing interests exist.
    • Comments:
      Erratum in: PLoS One. 2016 Dec 22;11(12):e0168029. doi: 10.1371/journal.pone.0168029.. (PMID: 28005919)
    • References:
      Int J Urol. 2008 May;15(5):377-88. (PMID: 18452452)
      J Clin Endocrinol Metab. 1990 Dec;71(6):1616-23. (PMID: 2172282)
      Hum Reprod. 2014 Aug;29(8):1801-9. (PMID: 24893607)
      Curr Diabetes Rev. 2012 Mar;8(2):131-43. (PMID: 22268394)
      Eur Urol. 2005 Jul;48(1):1-4. (PMID: 15951102)
      J Sex Med. 2014 Feb;11(2):583-94. (PMID: 24274237)
      Int J Urol. 2009 Feb;16(2):168-74. (PMID: 19054164)
      J Clin Endocrinol Metab. 2012 May;97(5):1508-16. (PMID: 22419720)
      J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45. (PMID: 18270261)
      Aging Male. 2005 Jun;8(2):59-74. (PMID: 16096160)
      N Engl J Med. 2010 Jul 8;363(2):123-35. (PMID: 20554979)
      J Clin Endocrinol Metab. 1995 Oct;80(10):3025-31. (PMID: 7559891)
      J Steroid Biochem. 1975 May;6(5):793-801. (PMID: 1102804)
      J Clin Endocrinol Metab. 2001 Feb;86(2):724-31. (PMID: 11158037)
      J Clin Endocrinol Metab. 2007 Nov;92(11):4241-7. (PMID: 17698901)
      Eur J Endocrinol. 2008 Nov;159(5):507-14. (PMID: 18955511)
      Diabetes Metab Syndr Obes. 2013 Oct 24;6:403-19. (PMID: 24179379)
      Eur J Endocrinol. 2003 Aug;149(2):145-52. (PMID: 12887292)
      Clin Endocrinol (Oxf). 2003 Jun;58(6):710-7. (PMID: 12780747)
      Horm Metab Res. 2015 Oct;47(11):846-54. (PMID: 25565093)
      Clin Endocrinol (Oxf). 2015 Dec;83(6):828-33. (PMID: 25777143)
      J Clin Endocrinol Metab. 2013 Aug;98(8):3289-97. (PMID: 23775354)
      Curr Opin Endocrinol Diabetes Obes. 2012 Jun;19(3):183-9. (PMID: 22531107)
      J Clin Endocrinol Metab. 2004 Dec;89(12):5920-6. (PMID: 15579737)
      Aging Male. 2013 Dec;16(4):164-8. (PMID: 24090209)
      Urology. 2015 Aug;86(2):287-90. (PMID: 26199166)
      Aging Male. 2012 Jun;15(2):85-9. (PMID: 22452321)
      Best Pract Res Clin Endocrinol Metab. 2013 Aug;27(4):557-79. (PMID: 24054931)
      Mol Cell Endocrinol. 2009 Feb 5;299(1):23-31. (PMID: 18761053)
      J Clin Endocrinol Metab. 1999 Oct;84(10):3666-72. (PMID: 10523012)
      J Clin Endocrinol Metab. 2010 Jun;95(6):2536-59. (PMID: 20525905)
      J Clin Endocrinol Metab. 2016 Jul;101(7):2647-57. (PMID: 26909800)
      PLoS One. 2014 Oct 08;9(10):e109346. (PMID: 25295520)
      J Endocrinol Invest. 2011 Jul-Aug;34(7):557-67. (PMID: 21720206)
      J Clin Endocrinol Metab. 2014 Apr;99(4):1357-66. (PMID: 24423283)
      Reprod Biol Endocrinol. 2015 Sep 30;13:111. (PMID: 26419465)
      J Clin Endocrinol Metab. 2002 Feb;87(2):589-98. (PMID: 11836290)
      Eur J Endocrinol. 2013 Feb 20;168(3):445-55. (PMID: 23425925)
      Ann Intern Med. 2003 Jan 7;138(1):10-6. (PMID: 12513039)
      Aging Male. 2009 Mar;12(1):5-12. (PMID: 18763169)
      J Clin Endocrinol Metab. 2006 Apr;91(4):1336-44. (PMID: 16368750)
      Clin Lab. 2012;58(3-4):281-90. (PMID: 22582502)
      Asian J Androl. 2016 Sep-Oct;18(5):747-53. (PMID: 26354142)
      J Urol. 2012 Apr;187(4):1369-73. (PMID: 22341266)
      Aging Male. 2005 Sep-Dec;8(3-4):203-6. (PMID: 16390747)
      J Androl. 2008 Nov-Dec;29(6):610-7. (PMID: 18599883)
      J Clin Endocrinol Metab. 2011 Aug;96(8):2430-9. (PMID: 21697255)
      J Sex Med. 2013 Jan;10(1):245-84. (PMID: 22971200)
      Geriatr Gerontol Int. 2010 Jan;10(1):32-9. (PMID: 20102380)
      BMJ. 2009 Feb 13;338:b352. (PMID: 19218325)
      J Clin Endocrinol Metab. 2007 Sep;92(9):3599-603. (PMID: 17595245)
      BMJ. 1996 Aug 31;313(7056):559-60. (PMID: 8790002)
      Med Clin North Am. 2011 May;95(3):507-23, x. (PMID: 21549875)
    • الرقم المعرف:
      0 (Sex Hormone-Binding Globulin)
      3XMK78S47O (Testosterone)
      9002-67-9 (Luteinizing Hormone)
    • الموضوع:
      Date Created: 20161007 Date Completed: 20170626 Latest Revision: 20260127
    • الموضوع:
      20260130
    • الرقم المعرف:
      PMC5053410
    • الرقم المعرف:
      10.1371/journal.pone.0164116
    • الرقم المعرف:
      27711240