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Is there a link between mean platelet volume and thrombotic events in antiphospholipid syndrome?

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  • المؤلفون: Korkmaz S;Korkmaz S; Uslu AU; Sahin S; Senel S; Sencan M
  • المصدر:
    Platelets [Platelets] 2014; Vol. 25 (5), pp. 343-7. Date of Electronic Publication: 2013 Aug 23.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9208117 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1635 (Electronic) Linking ISSN: 09537104 NLM ISO Abbreviation: Platelets Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Edinburgh ; New York : Churchill Livingstone, c1990-
    • الموضوع:
      Antiphospholipid Syndrome/*blood ; Mean Platelet Volume/*methods ; Thrombosis/*blood; Adult ; Female ; Humans ; Male ; Middle Aged ; Platelet Activation ; Young Adult
    • نبذة مختصرة :
      The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the production of antiphospholipid antibodies (aPL) that promote vascular thrombosis and pregnancy loss. APS can occur in the absence of underlying or associated disease (primary APS) or in combination with other diseases (secondary APS). Mean platelet volume (MPV) is largely regarded as a useful surrogate marker of platelet activation. We aimed to investigate if there is a relationship between MPV and thrombotic events in APS. The study consisted of 22 patients and 22 healthy controls. Group 1 is defined as all the patients in the first day of thrombotic event. Group 2 is defined as the same patient population three months after the thrombotic event. The erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Statistical analyses showed that MPV was significantly higher in group 1 than group 2 (p < 0.0001) and healthy controls (p < 0.05). However, there was no difference between group 2 and healthy controls (p = 0.888). WBC, hemoglobin and other platelet indices such as platelet distribution width and platecrit did not differ in groups. In conclusion, MPV was increased at initial thrombotic event of APS, and then it was normalized three months later by therapeutic interventions. To our knowledge, this is the first study demonstrating a correlation between MPV and thrombotic events in APS.
    • Contributed Indexing:
      Keywords: Antiphospholipid syndrome; mean platelet volume; thrombosis
    • الموضوع:
      Date Created: 20130827 Date Completed: 20150302 Latest Revision: 20140709
    • الموضوع:
      20260130
    • الرقم المعرف:
      10.3109/09537104.2013.824563
    • الرقم المعرف:
      23971949