Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance.

Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606 (Electronic) Linking ISSN: 17566606 NLM ISO Abbreviation: Mol Brain Subsets: MEDLINE

Original Publication: London : BioMed Central

Signal Transduction*; Brain/*physiology ; Receptors, Dopamine D1/*metabolism ; Receptors, Dopamine D2/*metabolism; Animals ; Humans

Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.

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R01 DA007223 United States DA NIDA NIH HHS

0 (Receptors, Dopamine D1)
0 (Receptors, Dopamine D2)

Date Created: 20110614 Date Completed: 20111130 Latest Revision: 20211020

20260130

PMC3138392

10.1186/1756-6606-4-26

21663703