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Metabolomics to study functional consequences in peroxisomal disorders

• Authors : Herzog, K.

• Source: Herzog , K 2017 , ' Metabolomics to study functional consequences in peroxisomal disorders ' , Doctor of

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S4 Fig - Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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C•G > T•A substitution abundances as fraction of reads for the same six fibroblast lines along the entire on-target amplicon.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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Oxygen Consumption Rate (OCR) assessed by mitochondrial stress test using the Seahorse XFe24 Analyzer on primary patient fibroblasts conditioned with either glucose or galactose.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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Off-target editing analysis in m.4291C-corrected fibroblasts.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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Tables containing the TALE protein sequences of the DdCBE-4291 and DdCBE-15150 editors, the primers used for sequencing and information on the nine sequence-dependent off-target sites.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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LNP-delivered modRNA encoding DdCBE efficiently corrects m.DNA mutations.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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Correction of m.4291T > C in primary patient-derived fibroblasts.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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Creation of m.15150G > A using DdCBE in human liver organoids.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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Original raw data used to generate Figs 1–4 and S1–S5.

• Authors : Indi P. Joore; Sawsan Shehata; Irena Muffels

Subjects: Biochemistry; Genetics; Molecular Biology

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