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Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

• Authors : Warfvinge, Rebecca; Geironson Ulfsson, Linda; Dhapola, Parashar

Subjects: Leukemia; Myelogenous; Chronic

• Source: eLife StemTherapy: National Initiative on Stem Cells for Regenerative Therapy eSSENCE: The e-Science Collaboration. 12

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Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs

• Authors : van Bergen, Wouter ( Utrecht University / Netherlands Proteomics Center); Baggelaar, Marc P. (Utrecht University / Netherlands Proteomics Center); Heck, Albert J. R. (Utrecht University / Netherlands Proteomics Center)

Subjects: ErbB Receptors Metabolism Antagonists & Inhibitors Chemistry; Humans; Protein Binding

• Source: ACS Chemical Biology 19(8), 1705-1718 (2024)

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Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity.

• Authors : Grahammer, F.; Dumoulin, B.; Gulieva, R.E.

Subjects: Animals; Humans; Mice

• Source: Kidney international, vol. 106, no. 5, pp. 856-869

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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

• Authors : Hobor, Sebastijan; Al Bakir, Maise; Hiley, Crispin T

Subjects: Humans; Tumor Suppressor Protein p53/genetics; Animals

• Source: TRACERx consortium , Hobor , S , Al Bakir , M , Hiley , C T , Skrzypski , M , Frankell , A M , Bakker , B , Watkins , T B K , Markovets , A , Dry , J R , Brown , A P , van der Aart , J , van den Bos ,

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A Receptor Tyrosine Kinase Inhibitor Sensitivity Prediction Model Identifies AXL Dependency in Leukemia

• Authors : Nasimian, Ahmad; Al Ashiri, Lina; Ahmed, Mehreen

Subjects: Humans; Sorafenib/therapeutic use; Tyrosine Protein Kinase Inhibitors

• Source: International Journal of Molecular Sciences StemTherapy: National Initiative on Stem Cells for Regenerative Therapy EpiHealth: Epidemiology for Health. 24(4)

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Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies.

• Authors : Najem, Ahmad; Krayem, Mohammad; Sabbah, Serena ...

Subjects: MAPKi; drug resistance; melanoma

• Source: Cells, 12 (14), 1855 (2023-07-14)

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Lazertinib in pretreated EGFR T790M-mutated advanced non-small cell lung cancer: A real-world multicenter study

• Authors : Hyunwook Kim; Beung-Chul Ahn; Jiyun Lee

Subjects: Aniline Compounds / therapeutic use; Carcinoma; Non-Small-Cell Lung* / drug therapy

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Preclinical Study of a Biparatopic METxMET Antibody-Drug Conjugate, REGN5093-M114, Overcomes MET-driven Acquired Resistance to EGFR TKIs in EGFR-mutant NSCLC

• Authors : Seung Yeon Oh; You Won Lee; Eun Ji Lee

Subjects: Carcinoma; Non-Small-Cell Lung* / drug therapy; Non-Small-Cell Lung* / genetics

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Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer

• Authors : Juliann Chmielecki; Jhanelle E Gray; Ying Cheng

Subjects: Carcinoma; Non-Small-Cell Lung* / drug therapy; Non-Small-Cell Lung* / genetics

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Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients with Non-small Cell Lung Cancer and Other Advanced Solid Tumors

• Authors : Christian Kollmannsberger; Herbert Hurwitz; Lyudmila Bazhenova

Subjects: Antineoplastic Agents* / therapeutic use; Carcinoma; Non-Small-Cell Lung* / drug therapy

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