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In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system

• Authors : Chu, Lianhe; Terasaki, Michishige; Mattsson, Charlotte L.

Subjects: chemical screen; diabetes; DYRK

• Source: Cell Chemical Biology EXODIAB: Excellence of Diabetes Research in Sweden. 29(9):5-1380

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N -Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents.

• Authors : Mostafa, Noha^1,2 (AUTHOR) ; Chen, Po-Jen^3,4 (AUTHOR) ; Darwish, Sarah S.^1,5 (AUTHOR)

• Source: Cancers. Jun2024, Vol. 16 Issue 11, p2033. 24p.

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The Nitro Group Reshapes the Effects of Pyrido[3,4- g ]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells.

• Authors : Borisevich, Sophia S.^1,2 (AUTHOR) ; Aksinina, Tatiana E.³ (AUTHOR) ; Ilyina, Margarita G.^1,2 (AUTHOR)

• Source: Cancers. Feb2024, Vol. 16 Issue 4, p834. 22p.

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Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

• Authors : Norman van Rhijn; Can Zhao; Narjes Al-Furaiji

Subjects: Science

• Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

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DYRK-family kinases regulate Candida albicans morphogenesis and virulence through the Ras1/PKA pathway

• Authors : Jessie MacAlpine; Zhongle Liu; Saif Hossain

Subjects: Candida albicans; Yak1 kinase; DYRK

• Source: mBio, Vol 14, Iss 6 (2023)

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The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA.

• Authors : Pastor F; International Center for Research in Infectiology (CIRI), INSERM U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, ENS de Lyon, Lyon, France.; Charles E

Subjects: Dyrk Kinases* ; Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/metabolism ; Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/genetics

• Source: PloS one [PLoS One] 2024 Oct 15; Vol. 19 (10), pp. e0311655. Date of Electronic Publication: 2024 Oct 15 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells.

• Authors : Vorwerk VA; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.; Wilms G

Subjects: Dyrk Kinases* ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/metabolism ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/genetics

• Source: Scientific reports [Sci Rep] 2024 Oct 13; Vol. 14 (1), pp. 23926. Date of Electronic Publication: 2024 Oct 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation.

• Authors : Li J; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, S.A.R.; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, S.A.R.

Subjects: Actins*/Actins*/Actins*/metabolism ; Cell Nucleus*/Cell Nucleus*/Cell Nucleus*/metabolism ; Chromatin*/Chromatin*/Chromatin*/metabolism

• Source: Nucleic acids research [Nucleic Acids Res] 2024 Aug 27; Vol. 52 (15), pp. 8897-8912.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Small molecule inhibitors of DYRK/CLK and uses thereof

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INHIBITORS OF DYRK AND PIM

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