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Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1.

• Authors : Parsonage, Gregory; Cuthbertson, Kevin; Endesh, Naima

Subjects: PHARMACEUTICAL chemistry; INTRACELLULAR calcium; MEMBRANE proteins

• Source: British Journal of Pharmacology; Aug2023, Vol. 180 Issue 16, p2039-2063, 25p, 10 Graphs

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A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase.

• Authors : Groom S; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Subjects: Analgesics, Opioid*/Analgesics, Opioid*/Analgesics, Opioid*/pharmacology ; Receptors, Opioid, mu*/Receptors, Opioid, mu*/Receptors, Opioid, mu*/metabolism; Rats

• Source: British journal of pharmacology [Br J Pharmacol] 2023 Apr; Vol. 180 (7), pp. 943-957. Date of Electronic Publication: 2020 Dec 27.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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Identification and characterization of select oxysterols as ligands for GPR17.

• Authors : Harrington, Anthony W.; Liu, Changlu; Phillips, Naomi

Subjects: OXYSTEROLS; HYDROXYCHOLESTEROLS; G protein coupled receptors

• Source: British Journal of Pharmacology; Feb2023, Vol. 180 Issue 4, p401-421, 21p, 2 Charts, 7 Graphs

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Hypothesis: Efficacy of early treatments with some NSAIDs in COVID-19: Might it also depend on their direct and/or indirect zinc chelating ability?

• Authors : Zamai L; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.; National Institute for Nuclear Physics (INFN)-Gran Sasso National Laboratory (LNGS), L'Aquila, Italy.

Subjects: Anti-Inflammatory Agents, Non-Steroidal*/Anti-Inflammatory Agents, Non-Steroidal*/Anti-Inflammatory Agents, Non-Steroidal*/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal*/Anti-Inflammatory Agents, Non-Steroidal*/Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use ; COVID-19*

• Source: British journal of pharmacology [Br J Pharmacol] 2023 Feb; Vol. 180 (3), pp. 279-286. Date of Electronic Publication: 2022 Dec 08.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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P2X7 receptor activation impairs antitumour activity of natural killer cells.

• Authors : Baroja-Mazo A; Biomedical Research Institute of Murcia (IMIB-Pascual Parrilla), University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain.; Peñín-Franch A

Subjects: Killer Cells, Natural*/Killer Cells, Natural*/Killer Cells, Natural*/metabolism ; Neoplasms*/Neoplasms*/Neoplasms*/metabolism ; Receptors, Purinergic P2X7*/Receptors, Purinergic P2X7*/Receptors, Purinergic P2X7*/metabolism

• Source: British journal of pharmacology [Br J Pharmacol] 2023 Jan; Vol. 180 (1), pp. 111-128. Date of Electronic Publication: 2022 Oct 03.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG-CoA reductase inhibition.

• Authors : Lindsay C; Department of Pharmacology, University of Oxford, Oxford, UK.; Musgaard M

Subjects: Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology ; Muscular Diseases*/Muscular Diseases*/Muscular Diseases*/chemically induced ; Muscular Diseases*/Muscular Diseases*/Muscular Diseases*/drug therapy

• Source: British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (21), pp. 4941-4957. Date of Electronic Publication: 2022 Aug 02.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice.

• Authors : Boer, Geke Aline; Hunt, Jenna Elizabeth; Gabe, Maria Buur Nordskov

• Source: British Journal of Pharmacology; Sep2022, Vol. 179 Issue 18, p4486-4499, 14p, 6 Graphs

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Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO‐dependent mechanism.

• Authors : Tingting, Wang; Tianqi, Fang; Xinyu, Wang

Subjects: SURFACE plasmon resonance; LISTERIA monocytogenes; MOLECULAR docking

• Source: British Journal of Pharmacology; Jul2022, Vol. 179 Issue 14, p3839-3858, 20p, 2 Color Photographs, 1 Black and White Photograph, 1 Diagram, 1 Chart, 7 Graphs

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The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine.

• Authors : Hill, Rob; Kruegel, Andrew C.; Javitch, Jonathan A.

Subjects: OPIOID analgesics; RESPIRATORY insufficiency; CYTOCHROME P-450 CYP3A

• Source: British Journal of Pharmacology; Jul2022, Vol. 179 Issue 14, p3875-3885, 11p, 4 Graphs

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Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice

• Authors : Geke Aline Boer; Jenna Elizabeth Hunt; Maria Buur Nordskov Gabe

Subjects: Blood Glucose; Mice, Inbred C57BL; Pharmacology

• Source: Boer, G A, Hunt, J E, Gabe, M B N, Windeløv, J A, Sparre-Ulrich, A H, Hartmann, B, Holst, J J & Rosenkilde, M M 2022, ' Glucose-dependent insulinotropic polypeptide receptor antagonist treatment

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