Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Exploring the interface between adolescent dysmenorrhoea and endometriosis: a protocol for a cohort and nested case-control study within the QResearch Database.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • المصدر:
      Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
    • الموضوع:
    • نبذة مختصرة :
      Introduction: Dysmenorrhoea affects up to 70%-91% of adolescents who menstruate, with approximately one-third experiencing severe symptoms with impacts on education, work and leisure. Dysmenorrhoea can occur without identifiable pathology, but can indicate underlying conditions, including congenital genital tract anomalies or endometriosis. There is a need for evidence about the management and incidence of dysmenorrhoea in primary care, the impact of treatments in adolescence on long-term outcomes and when to consider the possibility of endometriosis in adolescence.
      Methods and Analysis: This study aims to improve the evidence base for adolescents presenting to primary care with dysmenorrhoea. It comprises three interlinked studies. Using the QResearch Database, the study population includes all female at birth participants aged 10-19 years any time between 1 January 2000 and 30 June 2021. We will undertake (1) a descriptive study documenting the prevalence of coded dysmenorrhoea in primary care, stratified by demographic variables, reported using descriptive statistics; (2) a prospective open cohort study following an index cohort of all adolescents recorded as attending primary care with dysmenorrhoea and a comparator cohort of five times as many who have not, to determine the HR for a diagnosis of endometriosis, adenomyosis, ongoing menstrual pain or subfertility (considered singly and in combination) anytime during the study period; and (3) a nested case-control study for adolescents diagnosed with endometriosis, using conditional logistic regression, to determine the OR for symptom(s) preceding this diagnosis.
      Ethics and Dissemination: The project has been independently peer reviewed and received ethics approval from the QResearch Scientific Board (reference OX46 under REC 18/EM/0400).In addition to publication in peer-reviewed academic journals, we will use the combined findings to generate a resource and infographic to support shared decision-making about dysmenorrhoea in community health settings. Additionally, the findings will be used to inform a subsequent qualitative study, exploring adolescents' experiences of menstrual pain.
      Competing Interests: Competing interests: KV has received research funding from Bayer Healthcare and honoraria for talks and consultancy fees from Bayer Healthcare, AbbVie and Eli Lilly. JHC is an unpaid director of QResearch, a not-for-profit organisation which is a partnership between the University of Oxford and EMIS Health who supply the QResearch database used for this work. JHC is a founder and shareholder of ClinRisk ltd and was its medical director until 31st May 2019. ClinRisk Ltd produces open and closed source software to implement clinical risk algorithms (outside the scope of this work) into clinical computer systemsThe remaining authors declare no relevant conflict of interest.
      (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
    • References:
      J Pediatr Adolesc Gynecol. 2013 Jun;26(3):171-5. (PMID: 23507008)
      BMJ Sex Reprod Health. 2022 Jul;48(3):193-198. (PMID: 34782337)
      Gynecol Endocrinol. 2021 Apr;37(4):287-293. (PMID: 33569996)
      Eur J Obstet Gynecol Reprod Biol. 2017 Feb;209:46-49. (PMID: 27342684)
      J Obstet Gynaecol. 2020 Jan;40(1):83-89. (PMID: 31328629)
      Br J Gen Pract. 2007 Jun;57(539):470-6. (PMID: 17550672)
      Br J Gen Pract. 2021 Aug 26;71(710):e668-e676. (PMID: 33950856)
      J Pediatr Adolesc Gynecol. 2020 Apr;33(2):112-119. (PMID: 31812704)
      Hum Reprod. 1998 Apr;13(4):867-72. (PMID: 9619539)
      Eur J Contracept Reprod Health Care. 2017 Oct;22(5):334-343. (PMID: 28954555)
      PLoS One. 2019 Jul 24;14(7):e0220103. (PMID: 31339951)
      Pediatr Endocrinol Rev. 2015 Dec;13(2):512-20. (PMID: 26841639)
      J Pediatr Adolesc Gynecol. 2020 Dec;33(6):623-630. (PMID: 32736134)
      J Pediatr Adolesc Gynecol. 2021 Oct;34(5):643-648. (PMID: 33548448)
      Hum Reprod. 2013 Aug;28(8):2026-31. (PMID: 23739215)
      BJOG. 2008 Oct;115(11):1382-91. (PMID: 18715240)
      Pain. 2011 Sep;152(9):1966-1975. (PMID: 21524851)
      J Pediatr Adolesc Gynecol. 2006 Aug;19(4):271-5. (PMID: 16873031)
      J Pediatr Adolesc Gynecol. 2011 Oct;24(5 Suppl):S18-9. (PMID: 21856546)
      Br J Gen Pract. 2017 Dec;67(665):e816-e823. (PMID: 29109114)
      Hum Reprod Update. 2013 Sep-Oct;19(5):570-82. (PMID: 23727940)
      Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:138-150. (PMID: 29548642)
      BJOG. 2010 Jan;117(2):185-92. (PMID: 19874294)
      Br J Gen Pract. 2015 Feb;65(631):101-2. (PMID: 25624305)
      J Adolesc Health Care. 1988 Sep;9(5):398-402. (PMID: 3170307)
      Neurosci Biobehav Rev. 2020 Jan;108:866-876. (PMID: 31862211)
      Hum Reprod Update. 1999 Nov-Dec;5(6):621-6. (PMID: 10652971)
      Horm Res Paediatr. 2012;78(3):135-43. (PMID: 23051587)
      J Pediatr Adolesc Gynecol. 2016 Apr;29(2):97-103. (PMID: 26169662)
      Eur J Pediatr. 2019 Sep;178(9):1325-1332. (PMID: 31292729)
      Am J Obstet Gynecol. 2018 Mar;218(3):324.e1-324.e11. (PMID: 29247637)
    • Grant Information:
      C5255/A18085 United Kingdom Cancer Research UK; 204826/Z/16/Z Wellcome
    • Contributed Indexing:
      Keywords: EPIDEMIOLOGY; GYNAECOLOGY; PRIMARY CARE
    • الموضوع:
      Date Created: 20230214 Date Completed: 20230216 Latest Revision: 20230222
    • الموضوع:
      20240105
    • الرقم المعرف:
      PMC9930556
    • الرقم المعرف:
      10.1136/bmjopen-2022-069984
    • الرقم المعرف:
      36787972