Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE

Original Publication: Basel : MDPI, c2004-

Catechol O-Methyltransferase*/genetics ; Depression*/epidemiology ; Depression*/genetics ; Family Conflict* ; Self-Injurious Behavior*/epidemiology ; Self-Injurious Behavior*/genetics; Adolescent ; Asian People ; Child ; China ; Female ; Humans ; Male ; Mouth Mucosa ; Parents/psychology ; Psychology, Adolescent

Existing research suggests that parent-adolescent conflict is associated with increased risk for adolescent non-suicidal self-injury (NSSI). However, adolescent NSSI reactions to parent-adolescent conflicts exhibit large individual differences. This study sought to explore whether depressive symptoms mediates the relationship between parent-adolescent conflict and adolescent NSSI, and whether this mediating process is moderated by the COMT gene rs4680 polymorphism. A total of 673 adolescents (364 males, 309 females) in the age range of 12 to 15 years ( Mean age = 12.81 years, SD = 0.48) completed questionnaires regarding parent-adolescent conflict, depressive symptoms, and NSSI. Genomic DNA was extracted from saliva and buccal cells from each participant. Bootstrapping techniques displayed statistically significant moderated mediation. The results showed that the positive association between parent-adolescent conflict and adolescent NSSI was in fact mediated by depressive symptoms. Moreover, this indirect link was moderated by the COMT gene rs4680 polymorphism. Specifically, the risk effect of parent-adolescent conflict on adolescent NSSI via depressive symptoms was stronger for adolescents with Val/Val genotype than for those with Met/Met or Val/Met genotype. These findings underscore the importance of examining the interaction between genes and the environment to understand how and when parent-adolescent conflict impacts adolescent NSSI.

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Keywords: adolescent; depressive symptoms; non-suicidal self-injury (NSSI); parent-adolescent conflict; the COMT gene rs4680 polymorphism

EC 2.1.1.6 (COMT protein, human)
EC 2.1.1.6 (Catechol O-Methyltransferase)

Date Created: 20220909 Date Completed: 20220913 Latest Revision: 20230112

20240104

PMC9517911

10.3390/ijerph191710567

36078283