Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study).

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المؤلفون: Knorr S;Knorr S;Knorr S; Bytoft B; Bytoft B; Lohse Z; Lohse Z; Boisen AB; Boisen AB; Clausen TD; Clausen TD; Jensen RB; Jensen RB; Damm P; Damm P; Damm P; Beck-Nielsen H; Beck-Nielsen H; Holst JJ; Holst JJ; Holst JJ; Hartmann B; Hartmann B; Hartmann B; Møller HJ; Møller HJ; Højlund K; Højlund K; Gravholt CH; Gravholt CH; Jensen DM; Jensen DM; Jensen DM
المصدر:
Diabetes care [Diabetes Care] 2019 Aug; Vol. 42 (8), pp. 1560-1568. Date of Electronic Publication: 2019 Jun 04.
نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't
اللغة:
English

معلومة اضافية
- المصدر:
  Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
- بيانات النشر:
  Publication: Alexandria Va : American Diabetes Association
  Original Publication: New York, American Diabetes Assn.
- الموضوع:
  Diabetes Mellitus, Type 1*; Child of Impaired Parents/*statistics & numerical data ; Fatty Liver/*epidemiology; Adolescent ; Adult ; Age of Onset ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Infant, Newborn ; Male ; Middle Aged ; Pregnancy ; Pregnancy in Diabetics/epidemiology ; Prenatal Exposure Delayed Effects/epidemiology ; Prospective Studies ; Risk Factors ; Young Adult
- نبذة مختصرة :
  Objective: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the association between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163) (a marker of macrophage activation) and risk of fatty liver.
  Research Design and Methods: This study was a prospective nationwide follow-up study of offspring ( n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects ( n = 303). Mean age at the time of follow-up was 16.7 years (range 13.0-20.4 years). We used the fatty liver index (FLI) and waist-to-height ratio (WHtR) to evaluate the presence of fatty liver among the offspring. An FLI ≥60 or WHtR >0.469 were used as cutoff points for fatty liver.
  Results: More type 1 diabetes-exposed offspring had high FLI and WHtR indices compared with unexposed control subjects. We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.
  Conclusions: Intrauterine exposure to maternal type 1 diabetes and higher maternal prepregnancy BMI may predispose to fatty liver in the offspring. Offspring metabolic risk factors, including sCD163 levels, are associated with indices of fatty liver.
  (© 2019 by the American Diabetes Association.)
- Molecular Sequence:
  ClinicalTrials.gov NCT01559181
- الموضوع:
  Date Created: 20190607 Date Completed: 20200421 Latest Revision: 20200421
- الموضوع:
  20240105
- الرقم المعرف:
  10.2337/dc19-0571
- الرقم المعرف:
  31167890

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