Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Electrophysiological characterization of membrane permeability: from protein channels to nanoparticles
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- المؤلفون: Perini, Deborah Aurora
- المصدر:
TDX (Tesis Doctorals en Xarxa)
- الوصف المادي :
198 p.
- الموضوع:
- نوع التسجيلة:
Dissertation/Thesis
- اللغة:
English
- الدخول الالكتروني :
- معلومة اضافية
- Contributors:
University/Department: Universitat Jaume I. Escola de Doctorat
- Thesis Advisors:
Alcaraz, Antonio; Queralt-Martín, María
- بيانات النشر:
Universitat Jaume I, 2022.
- الموضوع:
2022
- نبذة مختصرة :
Doctorat internacional
- نبذة مختصرة :
Cell membrane permeability is modulated by complex dynamical structures created by objects interacting with the lipid bilayer. Paying attention to the kinetics of ion transport in response to different bioelectrochemical signals, we use planar bilayer electrophysiology to provide a perspective on membrane permeabilization mechanisms that goes from order to disorder as regards to the pore conformational dynamics. We first study stable channels shaped by large transmembrane proteins like OmpF. Next, we provide insights on lipid-peptide interactions leading to the formation of pores by Dynorphin A neuropeptides. Finally, we describe selective ion channels induced by large complex objects like plastic nanoparticles while the global bilayer integrity is maintained. Overall, the particular balance between hydrophobic and hydrophilic interactions is revealed in different ways in each system, either modulating the open and closed states of channels formed by membrane proteins or in the surface functionalization of nanoparticles that rules their interactions with membranes.
Programa de Doctorat en Ciències
- File Description:
application/pdf
- الرقم المعرف:
10.6035/14104.2022.782002
- Rights:
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
- الرقم المعرف:
edstdx.10803.687360
No Comments.