Medicine for the treatment of illnesses of the respiratory organs

5,310,560

07/879,339

May 05, 1992

Chenodeoxycholic acid and ursodeoxycholic acid, both being natural gallic acids, are well known for the treatment of cholesterin gallstones, of biliaric dyspepsia, and also chronic liver diseases (only Urso). The object of the present invention is the use of these acids or a combination thereof for the making of a medicine for treating acute or chronic inflammatory illnesses of the respiratory organs.

Widauer, Josef O. (Allschwil, ATX)

Medichemie AG (Ettingen, CHX)

I claim

1. A pharmaceutical gelatin capsule or polymer coated tablet for the treatment of acute and chronic inflammatory illness of the respiratory organs, comprising as the active principle chenodeoxycholic acid in admixture with suitable carriers or excipients, and a gelatin encapsulating agent or polymer coating to encapsulate or coat said active principle.

2. A method of treating a patient for the therapy of acute and chronic inflammatory illness of the respiratory organs which comprises the administration of an effective amount of said active principle according to claim 1.

3. A pharmaceutical gelatin capsule or polymer coated tablet for the treatment of acute and chronic inflammatory illness of the respiratory organs, comprising as the active principle ursodeoxycholic acid in admixture with suitable carriers or excipients, and a gelatin encapsulating agent or polymer coating to encapsulate or coat said active principle.

4. A method of treating a patient for the therapy of acute and chronic inflammatory illness of the respiratory organs which comprises the administration of an effective amount of said active principle according to claim 3.

5. A pharmaceutical gelatin capsule or polymer coated tablet for the treatment of acute and chronic inflammatory illness of the respiratory organs, comprising as the active principle a combination of chenodeoxycholic acid and ursodeoxycholic acid in admixture with suitable carriers or excipients, and a gelatin encapsulating agent or polymer coating to encapsulate or coat said active principle.

6. A method of treating a patient for the therapy of acute and chronic inflammatory illness of the respiratory organs which comprises the administration of an effective amount of said active principle according to claim 5.

7. A method to improve breathing difficulties for a patient with inflammatory illness of the respiratory organs comprising administering to said patient an effective amount of a gelatin capsule or polymer coated tablet comprising (1) an active principle selected from the group consisting of chenodeoxycholic acid, ursodeoxycholic acid and combinations thereof in admixture with suitable carriers or excipients, and (2) a gelatin encapsulating agent or polymer coating to encapsulate or coat said active principle.

8. A pharmaceutical gelatin capsule or polymer coated tablet comprising (1) an active principle selected from the group consisting of chenodeoxycholic acid, ursodeoxycholic acid and combinations thereof in admixture with suitable carriers or excipients for the treatment of a patient with inflammatory illness of the respiratory organs, and (2) a gelatin encapsulating agent or polymer coating to encapsulate or coat said active principle.

9. A pharmaceutical capsule or coated tablet of claim 8 wherein an effective amount of said active principle is used for the treatment of a patient with symptoms selected from the group consisting of chronically obstructed bronchitis, chronic pharyngitis, chronic tonsillitis and combinations thereof.

424/451; 424/456; 424/474; 514/170; 514/182

A61K 948; A61K 930

4681876 July 1987 Marple et al.
4917898 April 1990 Angelico et al.

"The Merck Index," 1989, No. 2044.
"The Merck Index," 1989, No. 9801.
Scand J. Rheumatology 4, 169-173, 1975.

edspgr.05310560