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Development of Prognostic Nomogram Based on Lipid Metabolic Markers and Lactate Dehydrogenase in Non-Metastatic Nasopharyngeal Carcinoma

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  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://www.dovepress.com/development-of-prognostic-nomogram-based-on-lipid-metabolic-markers-an-peer-reviewed-fulltext-article-JIR
    info:eu-repo/semantics/altIdentifier/doi/10.2147/JIR.S416801
  • معلومة اضافية
    • Publisher Information:
      Dove Press 2023-07-24
    • Added Details:
      Huang,Rong
      Chen,Kaihua
      Jiang,Yuting
      Li,Ling
      Zhu,Xiaodong
    • نبذة مختصرة :
      Rong Huang,1 Kaihua Chen,1 Yuting Jiang,1 Ling Li,1 Xiaodong Zhu1– 3 1Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, People’s Republic of China; 2Department of Oncology, Affiliated Wu-Ming Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 3Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education/Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Nanning, People’s Republic of ChinaCorrespondence: Xiaodong Zhu, Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, 71 He-Di Road, Nanning, 530021, People’s Republic of China, Tel +86 15778028340, Email zhuxdonggxmu@126.comPurpose: To establish and verify a comprehensive prognostic nomogram for predicting survival outcomes and improving the prognosis for non-metastatic nasopharyngeal carcinoma (NPC).Patients and Methods: Our retrospective study screened 613 cases of non-metastatic NPC who received radiotherapy from July 2012 to December 2016. A reliable nomogram was formulated for predicting overall survival (OS) and progression-free survival (PFS) using all independent predictors selected by Cox regression analysis. A comparison is conducted between the current staging and the predictive performance of the nomogram. Internal validation was performed in a single center using the validation cohort to assess predictive accuracy and discrimination.Results: High-density lipoprotein cholesterol, Epstein–Barr virus DNA and lactate dehydrogenase were determined to be valuable predictive indicators for predicting OS and PFS. Triglycerides were a valuable predictive indicator for predicting OS. Calibration curves demonstrated that the nomogram had remarkable correspondence between the prediction outcomes and the actual observations. Receiver operating characteristic curves showed that the nomogram had greater are
    • الموضوع:
      Journal of Inflammation Research; Original Research; info:eu-repo/semantics/article
    • Note:
      text/html
      English
    • Other Numbers:
      NZDMP oai:dovepress.com/85357
      1393900941
    • Contributing Source:
      DOVE MEDL PRESS LTD
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1393900941
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