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Biomarkers of Maternal Smoking and the Risk of Retinoblastoma in Offspring
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- المؤلفون: He, Di
- نوع التسجيلة:
Electronic Resource
- الدخول الالكتروني :
https://escholarship.org/uc/item/1kc267nj
https://escholarship.org/
- معلومة اضافية
- Publisher Information:
eScholarship, University of California 2022-11-17
- Added Details:
He, Di
Huang, Xiwen
Upppal, Karan
Coleman, Anne L
Walker, Douglas D
Ritz, Beate
Jones, Dean P
Heck, Julia
- نبذة مختصرة :
Purpose: Prior studies examining the risk of retinoblastoma with maternal smoking were inconclusive, likely due in part to the reliance on self-reported maternal smoking. This study uses biomarkers of tobacco smoking in neonatal dried blood spots to investigate associations between maternal smoking and retinoblastoma in offspring. Methods: We randomly selected 498 retinoblastoma cases and 895 controls born between 1983-2011 from a population-based case-control study in California. Maternal pregnancy-related smoking was measured using the following 3 metrics: provider or self-reported smoking during pregnancy, cotinine, and hydroxycotinine in neonatal blood. We employed multivariable logistic regression to estimate the effects of maternal tobacco smoking on retinoblastoma. Results: Using all metrics (biomarkers or self-report), maternal smoking late in pregnancy or early postpartum was related to retinoblastoma [all types; Odds Ratio (OR)=1.44, 95% Confidence Interval (CI) 1.00, 2.09]. Relying on cotinine or hydroxycotinine to ascertain smoking, maternal smoking was related to unilateral retinoblastoma (OR=1.66, 95% CI 1.08, 2.57).Conclusion: The results indicate that maternal smoking during pregnancy may be a risk factor for retinoblastoma, particularly among unilateral cases.
- الموضوع:
- Other Numbers:
CDLER oai:escholarship.org:ark:/13030/qt1kc267nj
qt1kc267nj
https://escholarship.org/uc/item/1kc267nj
https://escholarship.org/
1367393955
- Contributing Source:
UC MASS DIGITIZATION
From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
edsoai.on1367393955
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