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Vertical transmission of gut microbiome and antimicrobial resistance genes in infants exposed to antibiotics at birth
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- معلومة اضافية
- Publisher Information:
Oxford University Press 2021
- Added Details:
Li, W. (Weizhong)
Tapiainen, T. (Terhi)
Brinkac, L. (Lauren)
Lorenzi, H. A. (Hernan A.)
Moncera, K. (Kelvin)
Tejesvi, M. V. (Mysore V.)
Salo, J. (Jarmo)
Nelson, K. E. (Karen E.)
- نبذة مختصرة :
Vertical transmission of maternal microbes is a major route for establishing the gut microbiome in newborns. The impact of perinatal antibiotics on vertical transmission of microbes and antimicrobial resistance is not well understood. Using a metagenomic approach, we analyzed the fecal samples from mothers and vaginally delivered infants from a control group (10 pairs) and a treatment group (10 pairs) receiving perinatal antibiotics. Antibiotic-usage had a significant impact on the main source of inoculum in the gut microbiome of newborns. The control group had significantly more species transmitted from mothers to infants (P = 0.03) than the antibiotic-treated group. Approximately 72% of the gut microbial population of infants at 3–7 days after birth in the control group was transmitted from their mothers, versus only 25% in the antibiotic-treated group. In conclusion, perinatal antibiotics markedly disturbed vertical transmission and changed the source of gut colonization towards horizontal transfer from the environment to the infants.
- الموضوع:
- Note:
application/pdf
English
- Other Numbers:
OUX oai:oulu.fi:nbnfi-fe2021112557037
urn:nbn:fi-fe2021112557037
1287235722
- Contributing Source:
UNIV OF OULU
From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
edsoai.on1287235722
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