Contributors: Fantechi, Elvira Univ Florence, INSTM, Via Lastruccia 3, I-50019 Sesto Fiorentino, FI, Italy; Sangregorio, Claudio Univ Florence, INSTM, Via Lastruccia 3, I-50019 Sesto Fiorentino, FI, Italy; Fantechi, Elvira Univ Florence, Dept Chem U Schiff, Via Lastruccia 3, I-50019 Sesto Fiorentino, FI, Italy; Sangregorio, Claudio Univ Florence, Dept Chem U Schiff, Via Lastruccia 3, I-50019 Sesto Fiorentino, FI, Italy; Castillo, Paula M. Univ Cagliari, INSTM, I-09042 Monserrato, CA, Italy; Conca, Erika Univ Cagliari, INSTM, I-09042 Monserrato, CA, Italy; Cugia, Francesca Univ Cagliari, INSTM, I-09042 Monserrato, CA, Italy; Casula, Maria Francesca Univ Cagliari, INSTM, I-09042 Monserrato, CA, Italy; Castillo, Paula M. Univ Cagliari, Dept Chem & Geol Sci, I-09042 Monserrato, CA, Italy; Conca, Erika Univ Cagliari, Dept Chem & Geol Sci, I-09042 Monserrato, CA, Italy; Cugia, Francesca Univ Cagliari, Dept Chem & Geol Sci, I-09042 Monserrato, CA, Italy; Casula, Maria Francesca Univ Cagliari, Dept Chem & Geol Sci, I-09042 Monserrato, CA, Italy; Castillo, Paula M. Pablo Olavide Univ, Dept Phys Chem & Nat Syst, Seville, Spain; Castillo, Paula M. CABIMER Andalusian Ctr Mol Biol & Regenerat Med, Seville, Spain; Sangregorio, Claudio CNR ICCOM, Via Madonna Piano 10, I-50019 Sesto Fiorentino, FI, Italy; Sangregorio, Claudio INSTM, Via Madonna Piano 10, I-50019 Sesto Fiorentino, FI, Italy; Fantechi, Elvira CSIC, Catalan Inst Nanosci & Nanotechnol ICN2, Campus UAB, Barcelona 08193, Spain; Fantechi, Elvira Barcelona Inst Sci & Technol, Campus UAB, Barcelona 08193, Spain; Regione Autonoma della Sardegna under the R&D project 'Chitostrip'; Fondazione CARIPLO (project BaTMAN)
نبذة مختصرة : Gold-iron oxide composites were obtained by in situ reduction of an Au(III) precursor by an organic reductant (either potassium citrate or tiopronin) in a dispersion of preformed iron oxide ultrasmall magnetic (USM) nanoparticles. X-ray diffraction, transmission electron microscopy, chemical analysis and mid-infrared spectroscopy show the successful deposition of gold domains on the preformed magnetic nanoparticles, and the occurrence of either citrate or tiopronin as surface coating. The potential of the USM@Au nanoheterostructures as heat mediators for therapy through magnetic fluid hyperthermia was determined by calorimetric measurements under sample irradiation by an alternating magnetic field with intensity and frequency within the safe values for biomedical use. The USM@Au composites showed to be active heat mediators for magnetic fluid hyperthermia, leading to a rapid increase in temperature under exposure to an alternating magnetic field even under the very mild experimental conditions adopted, and their potential was assessed by determining their specific absorption rate (SAR) and compared with the pure iron oxide nanoparticles. Calorimetric investigation of the synthesized nanostructures enabled us to point out the effect of different experimental conditions on the SAR value, which is to date the parameter used for the assessment of the hyperthermic efficiency.
Processing Request
No Comments.