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Computational interrogation identified upstream TFs (predicted via ChEA3 using ENCODE ChIP-seq, ReMAP, and de novo motif screening; NES > 3.0) and miRNAs (miRDB; Target score ≥ 85, 80% validation accuracy). The integrated network (Cytoscape 3.9.1) comprised 63 nodes (TFs, biomarkers, miRNAs) and 60 confidence-weighted edges, with SP1 (RAG1-associated TF) and miR-26b-5p (top RAG1 miRNA, score = 97) highlighted as central hubs.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • الموضوع:
      2025
    • نبذة مختصرة :
      Computational interrogation identified upstream TFs (predicted via ChEA3 using ENCODE ChIP-seq, ReMAP, and de novo motif screening; NES > 3.0) and miRNAs (miRDB; Target score ≥ 85, 80% validation accuracy). The integrated network (Cytoscape 3.9.1) comprised 63 nodes (TFs, biomarkers, miRNAs) and 60 confidence-weighted edges, with SP1 (RAG1-associated TF) and miR-26b-5p (top RAG1 miRNA, score = 97) highlighted as central hubs.
    • الرقم المعرف:
      10.1371/journal.pone.0332041.g011
    • الدخول الالكتروني :
      https://doi.org/10.1371/journal.pone.0332041.g011
      https://figshare.com/articles/figure/Computational_interrogation_identified_upstream_TFs_predicted_via_ChEA3_using_ENCODE_ChIP-seq_ReMAP_and_de_novo_motif_screening_NES_3_0_and_miRNAs_miRDB_Target_score_85_80_validation_accuracy_The_integrated_network_Cytoscape_3_9_1_comprised/30078594
    • Rights:
      CC BY 4.0
    • الرقم المعرف:
      edsbas.A8861A95