نبذة مختصرة : Psoriasis and Systemic lupus erythematosus (SLE) are autoimmune diseases caused by multifactorial etiology, with involvement of genetic and non-genetic factors. The purpose of this case report is to clearly and succinctly present a rare association of autoimmune pathologies, which, according to some similar clinical features (arthralgia and cutaneous lesions), may interfere or delay the diagnosis of its coexistence. In addition, it is of paramount importance to the medical community to know about the treatment of this condition, since there is a possibility of exacerbation or worsening of one or both diseases. The combination of these diseases is very rare, so, the diagnosis is difficult and the treatment even more delicate, due to the possibility of exacerbation of one of them. We report the case of a middle-aged woman, carrier of Psoriasis who developed, subsequently, SLE. Treatment of acute SLE was performed with low dose Prednisone associated with Ciclosporin. The maintenance treatment is being performed with Adalimumab, with substantial improvement of arthralgia and psoriatic lesions. It was concluded then, that due to the limited number of psoriatic patients complicated with SLE, diagnosis and treatment of this condition can be challenging for the physician. ; Psoríase e Lúpus eritematoso sistêmico (LES) são doenças autoimunes de etiologia multifatorial, com envolvimento de fatores genéticos e não genéticos. O objetivo deste relato de caso é expor de maneira clara e sucinta uma associação rara de patologias autoimunes, que, de acordo com algumas características clínicas semelhantes (artralgia e lesões cutâneas), podem dificultar ou postergar o diagnóstico de sua coexistência. Além disso, é de suma importância à comunidade médica o conhecimento a respeito do tratamento desta condição, já que existe a possibilidade de exacerbação ou piora de uma, ou de ambas as doenças. Relata-se o caso de uma mulher de meia idade, portadora de psoríase e que desenvolveu, posteriormente, LES. O tratamento do LES agudo foi ...
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