نبذة مختصرة : In this short report, we describe an outbreak of COVID-19 caused by Omicron sub-variant BA.5.2.1 in highly vaccinated patients in a respiratory ward in large acute general hospital in North West London, UK. The attack rate was high (14/33 (42%)) but the clinical impact was relatively non severe including in patients who were at high risk of severe COVID-19. 12/14 patients had COVID-19 vaccinations. There was only one death due to COVID-19 pneumonitis. The findings of this outbreak investigation suggest that while transmissibility of Omicron BA.5.2.1 sub-variant is high, infections caused by this strain are non-severe in vaccinated patients, even if they are at high risk of severe COVID-19 infection.
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