Contributors: Finnish Institute of Occupational Health; Stress Research Institute; Stockholm University; School of Health Science; Jönköping University Sweden; Institute of Environmental Medicine; Karolinska Institutet Stockholm; National Research Centre for the Working Environment; National Research Centre for the Working Environment (NRCWE); Centre de recherche en épidémiologie et santé des populations (CESP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ); Department of Occupational and Environmental Medicine; Bispebjerg University Hospital; Department of Epidemiology and Public Health; University College of London London (UCL); Federal Institute for Occupational Safety and Health (BAuA); Institute for Medical Informatics, Biometry, and Epidemiology; Universität Duisburg-Essen Essen; The Netherlands Organisation for Applied Scientific Research (TNO); Department of Health Sciences; Mid Sweden University; Department of Public Health; School of Sociology, Social Policy, & Social Work; Queen's University Belfast (QUB); Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine; Umeå University; Department of psychology; University of Turku; Department of Psychology; Tufts University Medford; Department of Public Health Copenhagen; Faculty of Health and Medical Sciences; University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU); Folkhälsan Research Center; Occupational and Environmental Medicine; Uppsala University; Centre for Cognitive Ageing & Cognitive Epidemiology; University of Edinburgh; The IPD-Work Consortium is supported by the EU New OSHERA research programme (funded by the Finnish Work EnvironmentFund, Finland, the Swedish Research Council for Working Life andSocial Research, Sweden, the Danish National Research Centre for the Working Environment, Denmark), the Academy of Finland (grant132944), the BUPA Foundation (grant 22094477), and the Economicand Social Research Council, UK. POLS is funded by the Ministry ofSocial Affairs and Employment, Netherlands. MK is supported by theMedical Research Council and a professorial fellowship from theEconomic and Social Research Council, UK. AS is a British HeartFoundation professor. At the time of preparation of the manuscript, GDBwas a Wellcome Trust Fellow.; IPD-Work Consortium
نبذة مختصرة : International audience ; To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116,056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.
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