Metabolic Syndrome, Inflammation, Oxidative Stress, and Vitamin D Levels in Children and Adolescents with Obesity.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Oxidative Stress* ; Vitamin D*/blood ; Metabolic Syndrome*/blood ; Metabolic Syndrome*/metabolism ; Inflammation*/blood ; Inflammation*/metabolism ; Biomarkers*/blood; Humans ; Child ; Adolescent ; Female ; Male ; Body Mass Index ; Obesity/metabolism ; Obesity/blood ; Pediatric Obesity/blood ; Pediatric Obesity/metabolism ; Waist Circumference ; C-Reactive Protein/metabolism

Metabolic syndrome (MetS) is associated with systemic inflammation, oxidative stress, and hypovitaminosis D. Our aim was to determine whether vitamin D mediates inflammation and oxidative stress, assessed through selected biomarkers, in children with obesity and/or MetS. Eighty children with normal weight, overweight, or obesity were analyzed for serum vitamin D, C-reactive protein, leukocytes, adiponectin, monocyte chemoattractant protein-1, myeloperoxidase, interferon-inducible T-cell alpha chemoattractant (I-TAC/CXCL11), superoxide dismutase-1, fasting lipid and glucose levels, ultrasound-measured abdominal fat thickness, waist circumference, body mass index and blood pressure. Children with obesity or overweight had lower vitamin D levels, increased blood pressure, visceral and subcutaneous fat thickness, and higher leukocytes, C-reactive protein, and myeloperoxidase levels. Those with MetS also had lower adiponectin levels. Vitamin D levels are negatively correlated with body mass index, waist circumference, and visceral and subcutaneous fat thickness. Correlation, mediation, and regression analyses showed no link between vitamin D and inflammatory/oxidative stress variables. The novel biomarker I-TAC did not correlate with obesity or vitamin D status. Our results indicate that vitamin D does not significantly mediate inflammation or oxidative stress in children and adolescents with obesity and/or MetS. Selected inflammation/oxidative stress biomarkers appear to be altered primarily due to obesity rather than vitamin D status.

Transl Pediatr. 2017 Oct;6(4):397-407. (PMID: 29184820)
Front Biosci (Landmark Ed). 2011 Jan 01;16(5):1663-74. (PMID: 21196255)
Lancet. 2007 Jan 20;369(9557):201-7. (PMID: 17240286)
Endocr Rev. 2008 Dec;29(7):777-822. (PMID: 18971485)
Obes Facts. 2015;8(1):1-16. (PMID: 25765160)
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C375-C391. (PMID: 33356944)
Metab Syndr Relat Disord. 2020 Dec;18(10):462-470. (PMID: 32795106)
Biomedicines. 2021 Nov 23;9(12):. (PMID: 34944566)
Nutrients. 2023 Jul 05;15(13):. (PMID: 37447368)
J Pediatr. 2004 Oct;145(4):439-44. (PMID: 15480363)
Obesity (Silver Spring). 2012 Jul;20(7):1444-8. (PMID: 22262154)
Int J Obes (Lond). 2018 Aug;42(8):1406-1417. (PMID: 29795466)
Pediatr Gastroenterol Hepatol Nutr. 2020 May;23(3):189-230. (PMID: 32483543)
Eur J Clin Nutr. 2020 Nov;74(11):1498-1513. (PMID: 31959942)
Ann Nutr Metab. 2015;66(2-3):72-9. (PMID: 25612676)
Biomed Res Int. 2017;2017:7651815. (PMID: 28503574)
Int J Mol Sci. 2022 Jan 16;23(2):. (PMID: 35055140)
J Pediatr Endocrinol Metab. 2019 Sep 25;32(9):951-957. (PMID: 31444965)
Rev Endocr Metab Disord. 2023 Aug;24(4):611-631. (PMID: 37000372)
Ann N Y Acad Sci. 2013 Apr;1281:123-40. (PMID: 23356701)
Int J Obes Relat Metab Disord. 2001 Sep;25(9):1346-51. (PMID: 11571598)
Ther Adv Endocrinol Metab. 2020 Jul 01;11:2042018820930902. (PMID: 32655851)
Medicine (Baltimore). 2023 Aug 4;102(31):e34634. (PMID: 37543777)
Pediatrics. 2023 Feb 1;151(2):. (PMID: 36622115)
Front Endocrinol (Lausanne). 2023 Apr 20;14:1143755. (PMID: 37152969)
Ann Hematol. 2010 May;89(5):447-52. (PMID: 19841921)
World Health Organ Tech Rep Ser. 1995;854:1-452. (PMID: 8594834)
Nutrients. 2022 May 13;14(10):. (PMID: 35631190)
Nephrol Dial Transplant. 2013 Jul;28(7):1672-9. (PMID: 23468534)
Int J Obes Suppl. 2019 Apr;9(1):20-31. (PMID: 31391922)
Chest. 2020 Jul;158(1S):S12-S20. (PMID: 32658647)
Crit Rev Food Sci Nutr. 2020;60(4):660-669. (PMID: 30596263)
Microvasc Res. 2022 Jan;139:104254. (PMID: 34534571)
Hypertension. 2007 Jan;49(1):40-7. (PMID: 17130308)
Front Cardiovasc Med. 2020 Feb 25;7:22. (PMID: 32158768)
Proc Nutr Soc. 2015 May;74(2):115-24. (PMID: 25359323)
Int J Mol Sci. 2020 Sep 10;21(18):. (PMID: 32927656)
Obesity (Silver Spring). 2010 Mar;18(3):625-31. (PMID: 19779473)
Front Endocrinol (Lausanne). 2019 Mar 01;10:103. (PMID: 30881343)
Front Endocrinol (Lausanne). 2022 Jun 13;13:920340. (PMID: 35769088)
Front Immunol. 2024 Jul 04;15:1420883. (PMID: 39026686)
Am J Clin Nutr. 2020 May 1;111(5):1036-1047. (PMID: 32232398)
Nutrients. 2022 Jul 27;14(15):. (PMID: 35893929)
J Diabetes Res. 2016;2016:3271293. (PMID: 26783536)
Lancet. 2007 Jun 23;369(9579):2059-61. (PMID: 17586288)
Lancet. 2005 Apr 16-22;365(9468):1415-28. (PMID: 15836891)
Diagnostics (Basel). 2021 Mar 09;11(3):. (PMID: 33803348)
Clin Nutr. 2019 Dec;38(6):2851-2857. (PMID: 30635144)
J Steroid Biochem Mol Biol. 2020 Oct;203:105737. (PMID: 32818561)
Int J Mol Sci. 2023 Apr 26;24(9):. (PMID: 37175603)
Scientifica (Cairo). 2012;2012:205027. (PMID: 24278677)
J Pediatr. 2012 Nov;161(5):848-54. (PMID: 22677566)

IRP-2023/01-10 University Medical Center Maribor

Keywords: I-TAC/CXCL11; children; inflammation; mediation analysis; metabolic syndrome; obesity; oxidative stress; visceral fat thickness; vitamin D

1406-16-2 (Vitamin D)
0 (Biomarkers)
9007-41-4 (C-Reactive Protein)

Date Created: 20241016 Date Completed: 20241016 Latest Revision: 20241019

20241019

PMC11476559

10.3390/ijms251910599

39408928